骨类器官的构建策略、生物材料创新与再生医学应用前沿
Bone Organoids: Construction Strategies, Biomaterial Innovations, and Frontiers in Regenerative Medicine
DOI: 10.12677/hjbm.2026.161009, PDF,   
作者: 徐 雪*, 周玉婷, 杨 聪, 张晓南#:重庆医科大学附属口腔医院,重庆;口腔疾病与生物医学重庆市重点实验室,重庆;重庆市高校市级口腔生物医学工程重点实验室,重庆
关键词: 类器官骨组织工程骨再生医学生物材料构建方法Organoids Bone Tissue Engineering Bone Regeneration Medicine Biomaterials Construction Methods
摘要: 骨类器官作为体外模拟骨组织发育与功能的微型三维模型,在骨再生机制研究、药物筛选及个性化医疗策略开发中展现出巨大潜力。本综述系统梳理了骨类器官构建的核心策略,涵盖细胞来源的优化、生物材料的设计与微环境的精准调控,重点探讨了水凝胶、生物微粒、生物反应器等工程化技术在提升类器官结构完整性与功能成熟度方面的作用。文章进一步总结了骨类器官在疾病建模、药物筛选、毒性评估及个性化治疗中的最新应用进展,并指出当前面临的挑战,如血管化不足、标准化缺失与力学性能不足等问题。最后,对未来骨类器官在标准化构建、功能集成与临床转化方面的前景进行了展望,强调其在推动骨再生医学发展中的关键作用。
Abstract: Bone organoids, as miniature three-dimensional models that recapitulate bone development and physiological functions in vitro, offer a promising platform for investigating bone regeneration mechanisms, drug screening, and personalized therapeutic strategies. This review comprehensively outlines the core strategies for constructing bone organoids, focusing on the optimization of cell sources, the design of biomaterials, and the precise regulation of the microenvironment. We highlight the roles of engineered technologies—such as hydrogels, bioparticles, and bioreactor systems—in enhancing structural integrity and functional maturation. Furthermore, we summarize recent advances in the application of bone organoids for disease modeling, drug screening, toxicity assessment, and personalized medicine, while addressing existing challenges including inadequate vascularization, lack of standardization, and insufficient mechanical properties. Finally, we provide a forward-looking perspective on the standardization, functional integration, and clinical translation of bone organoids, underscoring their pivotal potential in advancing bone regenerative medicine.
文章引用:徐雪, 周玉婷, 杨聪, 张晓南. 骨类器官的构建策略、生物材料创新与再生医学应用前沿[J]. 生物医学, 2026, 16(1): 82-94. https://doi.org/10.12677/hjbm.2026.161009

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