中医药治疗子宫腺肌病相关信号通路研究进展
Research Progress of Traditional Chinese Medicine in the Treatment of Adenomyosis-Related Signaling Pathways
DOI: 10.12677/tcm.2026.151052, PDF,    科研立项经费支持
作者: 刘建宇：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨；韩凤娟*：黑龙江中医药大学附属第一医院妇科三科，黑龙江 哈尔滨
关键词: 子宫腺肌病；中医药；信号通路；研究进展；Adenomyosis； Traditional Chinese Medicine； Signaling Pathways； Research Advances
摘要: 子宫腺肌病作为一种常见且复杂的妇科疾病，严重影响女性的生活质量和生育功能，其发病机制涉及多种分子信号通路的异常调控。近年来，随着分子生物学技术的不断进步，相关信号通路在子宫腺肌病发病中的作用逐渐被揭示，尤其是炎症反应、细胞凋亡、细胞增殖及纤维化等路径的研究取得显著成果。中医药作为传统治疗体系，凭借其多靶点、多成分的特点，在调节这些关键通路方面表现出独特优势。本文系统综述了中医药对子宫腺肌病相关信号通路的调控机制，重点分析了中药复方、中药单体及中药药对对炎症、细胞凋亡及组织纤维化信号通路的影响，探讨其潜在的分子靶点及作用机制，为中医药治疗子宫腺肌病提供科学依据，并为未来中医药新药研发和临床应用指明方向。
Abstract: As a common and complex gynecological disease, adenomyosis seriously affects women’s quality of life and reproductive function. Its pathogenesis involves abnormal regulation of multiple molecular signaling pathways. In recent years, with the continuous progress of molecular biology technology, the role of related signaling pathways in the pathogenesis of adenomyosis has been gradually revealed, especially the research on inflammatory response, apoptosis, cell proliferation, and fibrosis has achieved remarkable results. As a traditional treatment system, traditional Chinese medicine has unique advantages in regulating these key pathways by virtue of its multi-target and multi-component characteristics. This paper systematically reviews the regulatory mechanism of traditional Chinese medicine on adenomyosis-related signaling pathways, focusing on the analysis of the effects of traditional Chinese medicine compounds, traditional Chinese medicine monomer and traditional Chinese medicine combination on inflammation, apoptosis, and tissue fibrosis signaling pathways, and exploring its potential molecular targets and mechanism of action. It provides a scientific basis for the treatment of adenomyosis with traditional Chinese medicine and points out the direction for the future development and clinical application of new drugs in traditional Chinese medicine.
文章引用：刘建宇, 韩凤娟. 中医药治疗子宫腺肌病相关信号通路研究进展[J]. 中医学, 2026, 15(1): 372-380. https://doi.org/10.12677/tcm.2026.151052

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