基于NF-κB信号通路治疗溃疡性结肠炎的研究进展
Research Progress on the Treatment of Ulcerative Colitis Targeting the NF-κB Signaling Pathway
DOI: 10.12677/acm.2026.161186, PDF,    科研立项经费支持
作者: 郭百晟, 康怀浩, 孙 奕, 阮文慧, 梁永鑫：济宁医学院临床医学院，山东 济宁；王建皓：济宁医学院精神卫生学院，山东 济宁；李 会*：济宁医学院基础医学院，山东 济宁
关键词: NF-κB信号通路；治疗；溃疡性结肠炎；NF-κB Signaling Pathway； Treatment； Ulcerative Colitis (UC)
摘要: 溃疡性结肠炎(ulcerative colitis, UC)是一种发生在结肠、直肠以及黏膜下层的非特异性慢性炎症性肠病。该病易复发，其发生与遗传、肠道微生态失调、免疫反应异常及环境因素等多因素有关。本文综合阐述UC的NF-κB信号通路机制，探讨以此通路为靶点的治疗策略，为UC的精准医疗提供理论依据和新的思路。
Abstract: Ulcerative colitis (UC) is a non-specific chronic inflammatory bowel disease that affects the colon and rectum, primarily involving the mucosa and submucosa. The disease is characterized by a high relapse rate and is associated with multiple factors, including genetic predisposition, gut microbiota dysbiosis, abnormal immune responses, and environmental elements. This article comprehensively elaborates on the role of the NF-κB signaling pathway in UC and discusses therapeutic strategies targeting this pathway, aiming to provide a theoretical foundation and novel insights for precision medicine in UC treatment.
文章引用：郭百晟, 康怀浩, 孙奕, 阮文慧, 梁永鑫, 王建皓, 李会. 基于NF-κB信号通路治疗溃疡性结肠炎的研究进展[J]. 临床医学进展, 2026, 16(1): 1445-1453. https://doi.org/10.12677/acm.2026.161186

参考文献

[1] 李会, 许昊, 胡天宇, 等. 蜂胶的药理作用及其治疗溃疡性结肠炎的研究进展[J]. 菏泽医学专科学校学报, 2024, 36(2): 74-77.
[2] 沈照峰. 基于真实世界的中医药治疗溃疡性结肠炎的临床应用研究和网状meta分析[D]: [硕士学位论文]. 南京: 南京医科大学, 2020.
[3] 黄墩煌, 王天相, 程思杰, 等. 基于NLRP3/NF-κB信号通路探讨燮理汤对溃疡性结肠炎的治疗作用[J]. 中医药通报, 2025, 24(6): 39-46.
[4] 陈颖, 郅扶旻, 徐洪涛, 等. 中医药调控NF-κB信号通路治疗糖尿病心肌病的研究进展[J]. 中国中医急症, 2025, 34(11): 1804-1807.
[5] Mitchell, S., Vargas, J. and Hoffmann, A. (2016) Signaling via the NF-κB System. WIREs Systems Biology and Medicine, 8, 227-241. [Google Scholar] [CrossRef] [PubMed]
[6] Hayden, M.S. and Ghosh, S. (2011) NF-κB in Immunobiology. Cell Research, 21, 223-244. [Google Scholar] [CrossRef] [PubMed]
[7] Mincheva-Tasheva, S. and Soler, R.M. (2012) NF-κB Signaling Pathways: Role in Nervous System Physiology and Pathology. The Neuroscientist, 19, 175-194. [Google Scholar] [CrossRef] [PubMed]
[8] Pasparakis, M. (2009) Regulation of Tissue Homeostasis by NF-κB Signalling: Implications for Inflammatory Diseases. Nature Reviews Immunology, 9, 778-788. [Google Scholar] [CrossRef] [PubMed]
[9] Siomek, A. (2012) NF-κB Signaling Pathway and Free Radical Impact. Acta Biochimica Polonica, 59, 323-331. [Google Scholar] [CrossRef] 
[10] Chen, Z.J. (2005) Ubiquitin Signalling in the NF-κB Pathway. Nature Cell Biology, 7, 758-765. [Google Scholar] [CrossRef] [PubMed]
[11] Atreya, I., Atreya, R. and Neurath, M.F. (2008) NF-κB in Inflammatory Bowel Disease. Journal of Internal Medicine, 263, 591-596. [Google Scholar] [CrossRef] [PubMed]
[12] Neurath, M.F. (2019) Targeting Immune Cell Circuits and Trafficking in Inflammatory Bowel Disease. Nature Immunology, 20, 970-979. [Google Scholar] [CrossRef] [PubMed]
[13] Li, Y., Liu, Q., Tang, J.H., et al. (2019) Regulatory Mechanism of Mesalazine on TLR4/MyD88-Dependent Pathway in Mouse Ulcerative Colitis Model. European Review for Medical and Pharmacological Sciences, 23, 6637-6644.
[14] Wahl, C., Liptay, S., Adler, G. and Schmid, R.M. (1998) Sulfasalazine: A Potent and Specific Inhibitor of Nuclear Factor κB. Journal of Clinical Investigation, 101, 1163-1174. [Google Scholar] [CrossRef] [PubMed]
[15] Egan, L.J., Mays, D.C., Huntoon, C.J., Bell, M.P., Pike, M.G., Sandborn, W.J., et al. (1999) Inhibition of Interleukin-1-Stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity. Journal of Biological Chemistry, 274, 26448-26453. [Google Scholar] [CrossRef] [PubMed]
[16] Ray, A. and Prefontaine, K.E. (1994) Physical Association and Functional Antagonism between the P65 Subunit of Transcription Factor NF-κB and the Glucocorticoid Receptor. Proceedings of the National Academy of Sciences of the United States of America, 91, 752-756. [Google Scholar] [CrossRef] [PubMed]
[17] Auphan, N., DiDonato, J.A., Rosette, C., Helmberg, A. and Karin, M. (1995) Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity through Induction of IκB Synthesis. Science, 270, 286-290. [Google Scholar] [CrossRef] [PubMed]
[18] Hayden, M.S. and Ghosh, S. (2014) Regulation of NF-κB by TNF Family Cytokines. Seminars in Immunology, 26, 253-266. [Google Scholar] [CrossRef] [PubMed]
[19] Kalliolias, G.D. and Ivashkiv, L.B. (2015) TNF Biology, Pathogenic Mechanisms and Emerging Therapeutic Strategies. Nature Reviews Rheumatology, 12, 49-62. [Google Scholar] [CrossRef] [PubMed]
[20] Van den Brande, J.M.H., Braat, H., van den Brink, G.R., Versteeg, H.H., Bauer, C.A., Hoedemaeker, I., et al. (2003) Infliximab but Not Etanercept Induces Apoptosis in Lamina Propria T-Lymphocytes from Patients with Crohn’s Disease. Gastroenterology, 124, 1774-1785. [Google Scholar] [CrossRef] [PubMed]
[21] Yuan, S., Wang, M., Han, J., Feng, C., Wang, M., Wang, M., et al. (2023) Improved Colonic Inflammation by Nervonic Acid via Inhibition of NF-κB Signaling Pathway of DSS-Induced Colitis Mice. Phytomedicine, 112, Article ID: 154702. [Google Scholar] [CrossRef] [PubMed]
[22] Gupta, S.C., Prasad, S., Kim, J.H., Patchva, S., Webb, L.J., Priyadarsini, I.K., et al. (2011) Multitargeting by Curcumin as Revealed by Molecular Interaction Studies. Natural Product Reports, 28, 1937-1955. [Google Scholar] [CrossRef] [PubMed]
[23] Shishodia, S., Amin, H.M., Lai, R. and Aggarwal, B.B. (2005) Curcumin (Diferuloylmethane) Inhibits Constitutive NF-κB Activation, Induces G1/S Arrest, Suppresses Proliferation, and Induces Apoptosis in Mantle Cell Lymphoma. Biochemical Pharmacology, 70, 700-713. [Google Scholar] [CrossRef] [PubMed]
[24] He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S. and Du, Z. (2015) Curcumin, Inflammation, and Chronic Diseases: How Are They Linked? Molecules, 20, 9183-9213. [Google Scholar] [CrossRef] [PubMed]
[25] Grammatikopoulou, M.G., Gkiouras, K., Theodoridis, X., Asteriou, E., Forbes, A. and Bogdanos, D.P. (2018) Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 10, Article 1737. [Google Scholar] [CrossRef] [PubMed]
[26] 温瑞瑞, 李思琦, 朱静, 等. 中药调控NF-κB信号通路改善溃疡性结肠炎的研究进展[J/OL]. 实用中医内科杂志: 1-9.
https://link.cnki.net/urlid/21.1187.R.20251016.1405.008, 2025-12-15.
[27] Podolin, P.L., Callahan, J.F., Bolognese, B.J., Li, Y.H., Carlson, K., Davis, T.G., et al. (2005) Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-Fluorophenyl)-3-Thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation. The Journal of Pharmacology and Experimental Therapeutics, 312, 373-381. [Google Scholar] [CrossRef] [PubMed]
[28] Tanaka, A. (2005) A Novel NF-B Inhibitor, IMD-0354, Suppresses Neoplastic Proliferation of Human Mast Cells with Constitutively Activated C-Kit Receptors. Blood, 105, 2324-2331. [Google Scholar] [CrossRef] [PubMed]
[29] Waelchli, R., Bollbuck, B., Bruns, C., Buhl, T., Eder, J., Feifel, R., et al. (2006) Design and Preparation of 2-Benzamido-Pyrimidines as Inhibitors of IKK. Bioorganic & Medicinal Chemistry Letters, 16, 108-112. [Google Scholar] [CrossRef] [PubMed]
[30] Grivennikov, S.I. and Karin, M. (2010) Dangerous Liaisons: STAT3 and NF-κB Collaboration and Crosstalk in Cancer. Cytokine & Growth Factor Reviews, 21, 11-19. [Google Scholar] [CrossRef] [PubMed]
[31] Zou, F., Mao, R., Yang, L., Lin, S., Lei, K., Zheng, Y., et al. (2016) Targeted Deletion of miR‐139‐5p Activates MAPK, NF-κB and stat3 Signaling and Promotes Intestinal Inflammation and Colorectal Cancer. The FEBS Journal, 283, 1438-1452. [Google Scholar] [CrossRef] [PubMed]
[32] Karin, M. and Clevers, H. (2016) Reparative Inflammation Takes Charge of Tissue Regeneration. Nature, 529, 307-315. [Google Scholar] [CrossRef] [PubMed]
[33] Arthur, J.S.C. and Ley, S.C. (2013) Mitogen-Activated Protein Kinases in Innate Immunity. Nature Reviews Immunology, 13, 679-692. [Google Scholar] [CrossRef] [PubMed]

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