LncRNA调控精神分裂症相关信号通路的研究进展
Research Progress on the Regulation of Schizophrenia-Related Signaling Pathways by LncRNA
DOI: 10.12677/acm.2026.161191, PDF,   
作者: 那千博, 刘怡杉：空军军医大学基础医学院学员五大队，陕西 西安；才延辉*：空军军医大学第一附属医院心身科，陕西 西安
关键词: 精神分裂症；LncRNA；信号通路；Schizophrenia； LncRNA； Signaling Pathway
摘要: 精神分裂症(Schizophrenia, SCZ)是一种常见的，慢性的，严重的精神障碍。目前研究普遍认为精神分裂症是由遗传因素和环境因素共同引起，且遗传作用更突出。长链非编码 RNA(Long non-coding RNA, lncRNA)参与基因表达水平的调控，与精神分裂症密切相关。本文综述了LncRNA在精神分裂症相关信号通路中的调控作用及其研究进展。这些信号通路涉及神经递质传递，神经保护，神经代谢以及炎症反应等多个方面。通过对这些调控机制的深入研究，有望为精神分裂症的早期诊断，预防和治疗提供新的思路和方法。本文还指出了当前研究中存在的问题和未来发展的方向，为进一步探索LncRNA在精神分裂症中的作用提供了有益的参考。
Abstract: Schizophrenia (SCZ) is a common, chronic, and severe mental disorder. Current research generally suggests that schizophrenia is caused by a combination of genetic and environmental factors, with genetics playing a more prominent role. Long non-coding RNAs (lncRNA) are involved in the regulation of gene expression and are closely associated with schizophrenia. This article reviews the regulatory role of lncRNA in schizophrenia-related signaling pathways and the associated research progress. These signaling pathways involve neurotransmitter transmission, neuroprotection, metabolism, and inflammatory responses. We intend to provide new ideas and methods for the early diagnosis, prevention, and treatment of schizophrenia by illuminating the mechanism of lncRNA in schizophrenia. This article also highlights the problems in current research and offers valuable information for further studies towards the role of lncRNA in schizophrenia.
文章引用：那千博, 刘怡杉, 才延辉. LncRNA调控精神分裂症相关信号通路的研究进展[J]. 临床医学进展, 2026, 16(1): 1491-1498. https://doi.org/10.12677/acm.2026.161191

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