能量代谢重编程调控破骨细胞分化的研究进展
The Research Progress in Energy Metabolism Reprogramming of Osteoclast Differentiation
DOI: 10.12677/hjbm.2026.161016, PDF,    国家自然科学基金支持
作者: 陈静容, 张红梅*:重庆医科大学附属口腔医院儿童口腔科,重庆;口腔疾病研究重庆市重点实验室,重庆;口腔生物医学工程重庆市高校市级重点实验室,重庆;重庆市卫生健康委口腔生物医学工程重点实验室,重庆;李明政*:口腔疾病研究重庆市重点实验室,重庆;口腔生物医学工程重庆市高校市级重点实验室,重庆;重庆市卫生健康委口腔生物医学工程重点实验室,重庆;重庆医科大学附属口腔医院口腔颌面外科,重庆
关键词: 破骨细胞代谢重编程氧化磷酸化糖酵解Osteoclasts Metabolic Reprogramming Oxidative Phosphorylation Glycolysis
摘要: 破骨细胞是高效吸收骨组织的主要细胞,在骨重塑过程中发挥重要作用。破骨细胞形成和活性的失调与多种骨病相关,如骨质疏松症、骨硬化症、类风湿关节炎和牙周炎。破骨细胞的代谢重编程不仅支持单核祖细胞向多核破骨细胞的表型转变,还为它们的分化及进行骨吸收功能提供必要能量。本文通过对代谢重编程在破骨细胞分化过程中的研究进行回顾,对不同代谢途径和机制进行综述。
Abstract: Osteoclasts are the primary cells responsible for efficient bone resorption and play a crucial role in bone remodeling. Dysregulation of osteoclast formation and activity is associated with various bone diseases, such as osteoporosis, osteopetrosis, rheumatoid arthritis and periodontitis. Metabolic reprogramming in osteoclasts not only supports the phenotypic transformation of mononuclear progenitors into multinucleated osteoclasts but also provides the necessary energy for their differentiation and bone-resorbing functions. This article reviews studies on metabolic reprogramming during osteoclast differentiation and summarizes the related metabolic pathways and mechanisms.
文章引用:陈静容, 张红梅, 李明政. 能量代谢重编程调控破骨细胞分化的研究进展[J]. 生物医学, 2026, 16(1): 154-162. https://doi.org/10.12677/hjbm.2026.161016

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