中药活性成分靶向肿瘤细胞铁死亡的分子机制研究
Molecular Mechanisms of Active Components in Traditional Chinese Medicine Targeting Ferroptosis in Tumor Cells
DOI: 10.12677/wjcr.2026.161002, PDF,   
作者: 陈璐璐：黑龙江中医药大学研究生院，黑龙江 哈尔滨；刘松江*：黑龙江中医药大学附属第一医院肿瘤科，黑龙江 哈尔滨
关键词: 铁死亡；脂质过氧化；信号通路；中药活性成分；Ferroptosis； Lipid Peroxidation； Signaling Pathway； Active Components of Traditional Chinese Medicine
摘要: 铁死亡是近年来肿瘤治疗领域的热门研究，是一种程序性的铁依赖性细胞死亡方式。中药活性成分具有多靶点、低毒性等优势，可通过多种途径调控铁死亡相关通路，诱导肿瘤细胞铁死亡。本文综述铁死亡的分子机制，探讨其在肿瘤治疗中的潜在应用价值，为新型抗肿瘤药物的开发提供理论依据，并对铁死亡通路抑制肿瘤的中药活性成分靶向的最新研究进展进行了深入的研究。
Abstract: Ferroptosis is a hot topic in cancer treatment research in recent years, representing a programmed iron-dependent form of cell death. Active ingredients in traditional Chinese medicine (TCM) offer advantages such as multi-target effects and low toxicity, and can regulate ferroptosis-related pathways through various mechanisms to induce ferroptosis in cancer cells. This review summarizes the molecular mechanisms of ferroptosis, explores its potential applications in cancer therapy, provides a theoretical foundation for the development of novel anti-cancer drugs, and delves into the latest research progress on targeting ferroptosis pathways with active ingredients from TCM to suppress tumors.
文章引用：陈璐璐, 刘松江. 中药活性成分靶向肿瘤细胞铁死亡的分子机制研究[J]. 世界肿瘤研究, 2026, 16(1): 8-12. https://doi.org/10.12677/wjcr.2026.161002

参考文献

[1] 张启立, 赵磊, 夏鹏飞, 等. 基于铁死亡理论的中医药防治肿瘤研究进展[J]. 中国实验方剂学杂志, 2021, 27(22): 222-231.
[2] Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A.J., Yang, W.S., Fridman, D.J., et al. (2007) RAS-RAF-MEK-Dependent Oxidative Cell Death Involving Voltage-Dependent Anion Channels. Nature, 447, 865-869. [Google Scholar] [CrossRef] [PubMed]
[3] Gao, M.P., Monian, P. and Jiang, X.J. (2015) Metabolism and Iron Signaling in Ferroptotic Cell Death. Oncotarget, 6, 35145-35146. [Google Scholar] [CrossRef] [PubMed]
[4] von Samson-Himmelstjerna, F.A., Kolbrink, B., Riebeling, T., Kunzendorf, U. and Krautwald, S. (2022) Progress and Setbacks in Translating a Decade of Ferroptosis Research into Clinical Practice. Cells, 11, Article 2134. [Google Scholar] [CrossRef] [PubMed]
[5] Miranda, M.R., Vestuto, V., Amodio, G., et al. (2024) Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of in Vitro and in Vivo Potential. Life, 14, Article 420. [Google Scholar] [CrossRef] [PubMed]
[6] Dong, H., Qiang, Z., Chai, D., Peng, J., Xia, Y., Hu, R. and Jiang, H. (2020) Nrf2 Inhibits Ferroptosis and Protects against Acute Lung Injury Due to Intestinal Ischemia Reperfusion via Regulating SLC7A11 and HO-1. Aging (Albany NY), 12, 12943-12959.
[7] Stepanić, V. and Kučerová-Chlupáčová, M. (2023) Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products. Molecules, 28, Article 475. [Google Scholar] [CrossRef] [PubMed]
[8] Zheng, D.H., Jin, S.K., Liu, P.S., et al. (2024) Targeting Ferroptosis by Natural Products in Pathophysiological Conditions. Archives of Toxicology, 98, 3191-3208. [Google Scholar] [CrossRef] [PubMed]
[9] 张若男, 潘婷, 于翔, 张明明, 谢韩, 等. 姜黄素通过lncRNA H19/miR-19b-3p/FTH1轴触发肺癌细胞的铁死亡[J]. 生物活性材料, 2022(13): 23-36.
[10] Gao, Z.W., Deng, G.H., Li, Y.J., Huang, H.C., Sun, X.G., et al. (2020) Actinidia Chinensis Planch Prevents Proliferation and Migration of Gastric Cancer Associated with Apoptosis, Ferroptosis Activation and Mesenchymal Phenotype Suppression. Biomedicine & Pharmacotherapy, 126, Article 110092. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, Y. and Xie, J. (2024) Targeting Ferroptosis Regulators by Natural Products in Colorectal Cancer. Frontiers in Pharmacology, 15, Article 1374722. [Google Scholar] [CrossRef] [PubMed]
[12] Tang, Y., Zhuang, Y., Zhao, C., Gu, S., Zhang, J., Bi, S., et al. (2024) The Metabolites from Traditional Chinese Medicine Targeting Ferroptosis for Cancer Therapy. Frontiers in Pharmacology, 15, Article 1280779. [Google Scholar] [CrossRef] [PubMed]
[13] Luo, N., Zhang, K.J., Li, X., Hu, Y. and Guo, L. (2025) Tanshinone IIA Destabilizes SLC7A11 by Regulating PIAS4-Mediated SUMOylation of SLC7A11 through KDM1A, and Promotes Ferroptosis in Breast Cancer. Journal of Advanced Research, 69, 313-327. [Google Scholar] [CrossRef] [PubMed]
[14] Zhan, J., Wang, J., Liang, Y., Zeng, X., Li, E. and Wang, H. (2023) P53 Together with Ferroptosis: A Promising Strategy Leaving Cancer Cells without Escape. Acta Biochimica et Biophysica Sinica, 56, 1-14. [Google Scholar] [CrossRef] [PubMed]
[15] Malik, Z., Parveen, R., Basist, P., et al. (2024) Solid Lipid Nanoparticles for Delivery of 5-Fluorouracil and Andrographolide: A Combination Approach for the Treatment of Cancer. BioNanoScience, 14, 3059-3077. [Google Scholar] [CrossRef] 
[16] Huang, X., Wang, M., Zhang, D., Zhang, C. and Liu, P. (2024) Advances in Targeted Drug Resistance Associated with Dysregulation of Lipid Metabolism in Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma, 11, 113-129. [Google Scholar] [CrossRef] [PubMed]

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