脓毒症相关免疫性血栓形成的相关机制及治疗研究进展
Research Progress on the Related Mechanisms and Treatments of Immune Thrombosis in Sepsis
DOI: 10.12677/acm.2026.161224, PDF,   
作者: 马宇昊, 牛亚军：西安医学院研究生工作部，陕西 西安；王 义*：西安交通大学附属儿童医院儿童重症医学科，陕西 西安
关键词: 免疫血栓形成；脓毒症；信号级联反应；中性粒细胞外诱捕网；弥散性血管内凝血；Immune Thrombosis； Sepsis； Signal Cascade； Neutrophil Extracellular Traps； Disseminated Intravascular Coagulation
摘要: 脓毒症仍是目前重要的全球健康问题，其特征为因机体感染后引起的免疫失调而引起的危及生命的器官功能障碍。免疫性血栓是在免疫系统激活和机体凝血途径的双重影响下形成的，虽然其作为为机体正常生理条件下的防御机制，但其在脓毒症中的异常激活会促使微血管血栓形成，引起器官缺血，最终引起弥散性血管内凝血的发生。本文通过对现有相关文献的综述，总结了脓毒症发生免疫性血栓形成的相关机制及治疗研究进展。
Abstract: Sepsis remains a major global health concern at present, characterized by life-threatening organ dysfunction caused by immune dysregulation secondary to infection in the body. Immune thrombosis is formed under the dual influence of immune system activation and the body’s coagulation pathways. Although it acts as a defensive mechanism under normal physiological conditions, its abnormal activation during sepsis can promote the formation of microvascular thrombosis, induce organ ischemia, and ultimately lead to the development of disseminated intravascular coagulation (DIC). By reviewing the existing relevant literature, this paper summarizes the research progress on the related mechanisms and treatments of immune thrombosis in sepsis.
文章引用：马宇昊, 牛亚军, 王义. 脓毒症相关免疫性血栓形成的相关机制及治疗研究进展[J]. 临床医学进展, 2026, 16(1): 1761-1769. https://doi.org/10.12677/acm.2026.161224

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