基于PHD-HIF轴探讨黑地黄方改善肾性贫血的机制
Exploring the Mechanism of Hei Di Huang Formula in Ameliorating Renal Anemia via the PHD-HIF Axis
DOI: 10.12677/acm.2026.161240, PDF,    科研立项经费支持
作者: 朱 江, 康 娜*, 常淑婷, 张韵林：陕西中医药大学第一临床医学院，陕西 咸阳
关键词: 黑地黄方；肾性贫血；PHD-HIF轴；机制；Hei Di Huang Formula； Renal Anemia； PHD-HIF Axis； Mechanism
摘要: 目的：探讨黑地黄方改善肾性贫血的作用机制与其影响脯氨酰羟化酶–低氧诱导因子(PHD-HIF)轴有关。方法：通过归纳分析现有文献，发现PHD-HIF轴是治疗肾性贫血的重要通路，黑地黄方能有效改善肾性贫血，通过文献检索黑地黄方组方药物的现代药理学研究结果，分析其影响PHD-HIF轴的活性成分与作用基础，从而论证黑地黄方可能通过影响PHD-HIF轴改善肾性贫血。结果：黑地黄方能有效改善肾性贫血，其组方药物中的有效成分能影响PHD活性与HIF-1α稳定性。结论：黑地黄方可能通过PHD-HIF轴改善肾性贫血。
Abstract: Objective: To investigate whether the mechanism by which the Hei Di Huang Formula (HDHF) ameliorates renal anemia (RA) is related to its influence on the prolyl hydroxylase-hypoxia-inducible factor (PHD-HIF) axis. Methods: Through a review and analysis of existing literature, the PHD-HIF axis was identified as a crucial pathway for treating RA. Given the established efficacy of HDHF in improving RA, modern pharmacological research findings on the constituent herbs of HDHF were retrieved. The active components and their potential basis for influencing the PHD-HIF axis were analyzed to evaluate the hypothesis that HDHF ameliorates RA by modulating this axis. Results: HDHF is effective in ameliorating RA. The active compounds in HDHF can influence PHD activity and HIF-1α stability. Conclusion: HDHF may ameliorate renal anemia by modulating the PHD-HIF axis.
文章引用：朱江, 康娜, 常淑婷, 张韵林. 基于PHD-HIF轴探讨黑地黄方改善肾性贫血的机制[J]. 临床医学进展, 2026, 16(1): 1901-1908. https://doi.org/10.12677/acm.2026.161240

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