麦冬皂苷对心肌缺血再灌注损伤的保护作用及其机制的研究进展
Research Progress on the Protective Effects and Mechanisms of Ophiopogonin against Myocardial Ischemia-Reperfusion Injury
摘要: 本文综述了麦冬皂苷对心肌缺血再灌注损伤的保护作用及其机制。心肌缺血再灌注损伤是指心肌在缺血后恢复血流时反而出现更严重的损伤，其机制涉及氧化应激、钙离子超载、炎症反应及细胞凋亡等。麦冬皂苷通过抗氧化、抗炎、调节细胞钙离子平衡及保护细胞器功能等多种机制，显著减轻心肌缺血再灌注损伤。体外实验表明，麦冬皂苷D (OPD)可浓度依赖性地提高细胞存活率，抑制氧化应激、减少钙离子超载、降低细胞凋亡率。体内实验显示，OPD可显著提升心功能指标，缩小梗死面积，降低炎症因子水平。未来研究应进一步探索其分子机制，优化制剂工艺，解决临床应用中的难题，推动其在心血管疾病治疗中的广泛应用。
Abstract: This review summarizes the protective effects and mechanisms of ophiopogonin D against myocardial ischemia-reperfusion injury (MIRI). MIRI is a severe pathological condition where the restoration of blood flow to ischemic myocardium paradoxically exacerbates tissue damage. The underlying mechanisms involve oxidative stress, calcium overload, inflammatory responses, and apoptosis. Ophiopogonin D exerts significant protective effects against MIRI through multiple mechanisms, including antioxidant, anti-inflammatory, calcium homeostasis regulation, and protection of cellular organelle functions. In vitro studies have shown that ophiopogonin D can dose-dependently increase cell viability, inhibit oxidative stress, reduce calcium overload, and decrease apoptosis rates. In vivo experiments have demonstrated that ophiopogonin D can significantly improve cardiac function indicators, reduce infarct size, and lower levels of inflammatory factors. Future research should further explore its molecular mechanisms, optimize formulation processes, and address challenges in clinical application to promote its widespread use in the treatment of cardiovascular diseases.
文章引用：李俊达, 王莹威. 麦冬皂苷对心肌缺血再灌注损伤的保护作用及其机制的研究进展[J]. 临床医学进展, 2026, 16(1): 1909-1916. https://doi.org/10.12677/acm.2026.161241

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