基于GH/IGF-1的AGHD患者骨质疏松风险预测模型建立研究

Establishment of an Osteoporosis Risk Prediction Model for Adult Growth Hormone Deficiency (AGHD) Patients Based on GH/IGF-1

摘要: 生长激素(GH)和胰岛素样生长因子-1 (IGF-1)在骨代谢中发挥关键作用，成人生长激素缺乏症患者(AGHD) GH/IGF-1水平下降，常伴随骨代谢异常，显著增加骨质疏松风险，临床上早期识别该类人群骨量改变对于预防和诊疗骨质疏松具有重要意义。目前，已有大量骨质疏松风险预测工具，但对AGHD患者早期进行骨量监测仍缺乏相关研究。本文就上述内容进行综述并进一步探讨AGHD患者基于GH/IGF-1进行骨质疏松风险预测模型建立的必要性、可行性及总结临床预测模型建立的基本步骤，为临床诊疗决策提供相关理论依据。

Abstract: Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) play an important role in bone metabolism. Patients with adult growth hormone deficiency (AGHD) exhibit reduced GH/IGF-1 levels, which are frequently associated with impaired bone metabolism and a substantially elevated risk of osteoporosis. Clinically, the early identification of bone mass alterations in this patient population holds significant importance for the prevention, diagnosis, and management of osteoporosis. Now, numerous risk prediction tools for osteoporosis have been developed; however, there remains a paucity of relevant research focusing on early bone mass monitoring in AGHD patients. This review summarizes the aforementioned evidence, further explores the necessity and feasibility of establishing a GH/IGF-1-based osteoporosis risk prediction model specifically for AGHD patients, and outlines the fundamental steps for constructing clinical prediction models. Ultimately, this work aims to provide a theoretical basis to inform clinical diagnostic and therapeutic decision-making.