妊娠期糖尿病预测中胰岛素抵抗替代指标的研究进展
Research Progress on Alternative Indicators of Insulin Resistance in the Prediction of Gestational Diabetes Mellitus
摘要: 妊娠期糖尿病(GDM)是妊娠期常见的疾病之一，对孕产妇及胎儿的健康均构成潜在威胁。胰岛素抵抗(IR)被认为是参与GDM发生的重要机制之一。近年来，研究者们发现甘油三酯–葡萄糖指数(TyG)、甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C)、甘油三酯葡萄糖体质量指数(TyG-BMI)以及胰岛素抵抗代谢评分(METS-IR)等新型胰岛素抵抗替代指标，其对GDM的预测价值也逐步被验证。本文系统检索PubMed、CNKI等数据库，对新型IR替代指标的研究进展及其与GDM的相关性展开综述，旨在为GDM的早期识别提供夯实基础。
Abstract: Gestational diabetes mellitus (GDM) is one of the most common gestational disorders, posing potential threats to the health of both pregnant women and fetuses. Insulin resistance (IR) is recognized as a key mechanism involved in the pathogenesis of GDM. In recent years, researchers have identified several novel surrogate markers for insulin resistance, including the triglyceride-glucose index (TyG), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), triglyceride-glucose body mass index (TyG-BMI), and metabolic score for insulin resistance (METS-IR). Their predictive value for GDM has been gradually validated in clinical studies. This review systematically retrieves literature from databases such as PubMed and CNKI, summarizing the research progress of these novel IR surrogate markers and their correlation with GDM. The aim is to provide a solid foundation for the early identification of GDM.
文章引用：曾无虑, 张朝霞, 黄大元. 妊娠期糖尿病预测中胰岛素抵抗替代指标的研究进展[J]. 临床个性化医学, 2026, 5(1): 384-391. https://doi.org/10.12677/jcpm.2026.51054

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