NRIP1在肿瘤发生中的研究进展
Advances in the Study of NRIP1 in Tumor Development
DOI: 10.12677/jcpm.2026.51056, PDF,    科研立项经费支持
作者: 高晓晴, 刘子贤, 冯钰铭:济宁医学院临床医学院(附属医院),山东 济宁;朱珣珣:济宁医学院附属医院医学研究中心,山东 济宁;张 颢*:济宁医学院附属医院血液科,山东 济宁
关键词: NRIP1/RIP140肿瘤调控机制NRIP1/RIP140 Tumor Regulation Mechanism
摘要: 核受体相互作用蛋白1 (nuclear receptor interacting protein 1, NRIP1),也称为受体相互作用蛋白140 (Receptor Interacting Protein of 140 kDa, RIP140),是一种转录共调节因子,参与调控多种生理过程,其功能异常可能导致疾病发生。与其他主要发挥共激活或共抑制作用的共调节因子不同,NRIP1在基因调控中具有独特的双重功能——既能作为共激活因子,也能作为共抑制因子发挥作用。近年来,随着研究的深入,科学家们逐渐揭示了NRIP1在肿瘤发生发展过程中的重要调控作用。本文重点综述NRIP1在乳腺癌、口腔鳞状细胞癌、肠道肿瘤、血液系统肿瘤等多种恶性肿瘤中的分子调控机制。
Abstract: Nuclear receptor interacting protein 1 (NRIP1), also known as receptor interacting protein of 140 kDa (RIP140), is a transcriptional co-regulator involved in the regulation of various physiological processes, and its dysfunction may lead to disease. Unlike other co-regulators that play a major role in co-activation or co-inhibition, NRIP1 has a unique dual function in gene regulation: it can act as both a co-activator and a co-inhibitor. In recent years, with the deepening of research, scientists have gradually revealed the important regulatory role of NRIP1 in the development of tumors. This article focuses on the molecular regulation mechanism of NRIP1 in breast cancer, oral squamous cell carcinoma, intestinal tumors, hematological tumors and other malignant tumors.
文章引用:高晓晴, 朱珣珣, 刘子贤, 冯钰铭, 张颢. NRIP1在肿瘤发生中的研究进展[J]. 临床个性化医学, 2026, 5(1): 398-408. https://doi.org/10.12677/jcpm.2026.51056

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