中医药调控Notch信号通路防治IgA肾病的研究进展
Research Progress on the Prevention and Treatment of IgA Nephropathy by Regulating the Notch Signaling Pathway of Traditional Chinese Medicine
DOI: 10.12677/jcpm.2026.51063, PDF,   
作者: 高莹莹：黑龙江省中医药科学院研究生院，黑龙江 哈尔滨；徐敢风*：黑龙江省中医医院肾十科，黑龙江 哈尔滨
关键词: IgA肾病；信号通路；机制；中药药理学；中药提取物；综述；IgA Nephropathy； Signaling Pathway； Mechanism； Chinese Pharmacology； Chinese Herb Extracts； Review
摘要: IgA肾病是世界范围内最常见的一种慢性原发性肾小球疾病，临床表现多样，主要表现为镜下血尿或肉眼血尿，可伴有不同程度蛋白尿、高血压和肾功能损伤，是导致终末期肾脏病的重要病因之一，近年来研究发现，Notch信号通路及其相关信号通路在IgAN发病机制中起着重要的转导作用，调控信号通路在氧化应激、延缓肾脏纤维化中起着重要作用。近年来中医药通过调控Notch信号通路防治IgA肾病取得了一定的进展。本文将总结归纳近年来中医药干预Notch信号通路治疗IgA肾病现有的研究成果，为IgA肾病新防治药物的研发及中医药治疗IgA肾病提供理论参考依据。
Abstract: IgA nephropathy is the most common chronic primary glomerular disease in the world. It has a variety of clinical manifestations. It is mainly manifested as hematuria under the microscope or naked hematuria, which can be accompanied by different degrees of proteinuria, hypertension and renal damage. It is one of the important causes of end-stage renal disease. In recent years, studies have found that the Notch signaling pathway and its related signal pathways play an important role in the pathogenesis of IgAN, and the regulatory signal pathway plays an important role in oxidative stress and delaying renal fibrosis. In recent years, traditional Chinese medicine has made some progress in the prevention and treatment of IgA kidney disease by regulating the Notch signaling pathway. This article will summarize the existing research results of traditional Chinese medicine in the intervention of Notch signaling pathway in the treatment of IgA nephropathy in recent years, and provide a theoretical reference basis for the research and development of new drugs for IgA nephropathy and the treatment of IgA nephropathy in traditional Chinese medicine.
文章引用：高莹莹, 徐敢风. 中医药调控Notch信号通路防治IgA肾病的研究进展[J]. 临床个性化医学, 2026, 5(1): 453-459. https://doi.org/10.12677/jcpm.2026.51063

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