大气细颗粒物组分对心肺系统健康影响的研究进展
Research Progress on the Impact of Fine Particulate Matter Components in the Atmosphere on Cardiopulmonary System Health
DOI: 10.12677/acm.2026.161268, PDF,   
作者: 金 玉, 凤志慧*：山东大学公共卫生学院劳动卫生与环境卫生学系，山东 济南
关键词: PM2.5组分；心血管系统疾病；呼吸系统疾病；PM2.5 Components； Cardiovascular System Diseases； Respiratory System Diseases
摘要: 细颗粒物(fine particulate matter, PM2.5)作为空气污染的重要组成部分，对公众健康构成严重威胁，已成为全球公共卫生领域面临的重大挑战。近年来，越来越多的流行病学研究表明，无论短期还是长期暴露于PM2.5均与心血管和呼吸系统疾病的发生与发展密切相关。然而，相较于PM2.5整体质量浓度，其不同化学组分对心肺系统健康的影响研究仍十分缺乏，相关证据相对有限。因此，本文通过梳理近年来相关文献，综述PM2.5组分暴露对心肺系统健康效应的研究进展，以期为未来组分健康效应研究提供参考，为制定更精准的环境治理策略、促进人群心肺健康提供科学依据。
Abstract: Fine particulate matter (PM2.5), as an important component of air pollution, poses a serious threat to public health and has become a major challenge in the field of global public health. In recent years, a large number of epidemiological studies have shown that both short-term and long-term exposure to PM2.5 is closely related to the occurrence and development of cardiovascular and respiratory diseases. However, compared with the overall mass concentration of PM2.5, research on the impact of its different chemical components on the health of the cardiopulmonary system is still very scarce, and the relevant evidence is relatively limited. Therefore, this paper reviews the research progress on the health effects of PM2.5 component exposure on the cardiopulmonary system by reviewing relevant literature in recent years, with the aim of providing a reference for future research on the health effects of components and offering a scientific basis for formulating more precise environmental governance strategies and promoting cardiopulmonary health in the population.
文章引用：金玉, 凤志慧. 大气细颗粒物组分对心肺系统健康影响的研究进展[J]. 临床医学进展, 2026, 16(1): 2123-2129. https://doi.org/10.12677/acm.2026.161268

参考文献

[1] 慕芸. PM2.5组分与肺功能——基于山东省青年人群队列的实证研究[D]: [硕士学位论文]. 济南: 山东财经大学, 2025.
[2] 蒋叶. 大气PM2.5组分长期暴露与新发心血管疾病关联及代谢危险因素的中介效应研究[D]: [硕士学位论文]. 成都: 四川大学, 2023.
[3] 刘麟炯. PM2.5组分长期暴露与国人心血管疾病及全因死亡的关联性研究[D]: [硕士学位论文]. 武汉: 武汉科技大学, 2022.
[4] 李宇轩. 细颗粒物(PM2.5)及其组分与精神分裂症患者心血管风险的关系[D]: [硕士学位论文]. 合肥: 安徽医科大学, 2023.
[5] Liang, R., Chen, R., Yin, P., van Donkelaar, A., Martin, R.V., Burnett, R., et al. (2022) Associations of Long-Term Exposure to Fine Particulate Matter and Its Constituents with Cardiovascular Mortality: A Prospective Cohort Study in China. Environment International, 162, Article ID: 107156. [Google Scholar] [CrossRef] [PubMed]
[6] Yang, J., Zhou, M., Li, M., Yin, P., Hu, J., Zhang, C., et al. (2020) Fine Particulate Matter Constituents and Cause-Specific Mortality in China: A Nationwide Modelling Study. Environment International, 143, Article ID: 105927. [Google Scholar] [CrossRef] [PubMed]
[7] 李碧霞. 广州市大气颗粒物及其组分对人群疾病死亡影响的研究[D]: [硕士学位论文]. 广州: 暨南大学, 2021.
[8] 龚天宜. 北京市黑碳与PM2.5的人群健康效应研究[D]: [硕士学位论文]. 成都: 成都信息工程大学, 2019.
[9] 张莹, 辛金元, 张小玲, 等. 北京市气温与黑碳和PM2.5对疾病死亡影响的交互效应[J]. 中国环境科学, 2020, 40(7): 3179-3187.
[10] 欧奕含, 张小玲, 张莹, 等. 西安BC、PM2.5与气温协同对心脑血管疾病死亡的影响[J]. 中国环境科学, 2021, 41(9): 4415-4425.
[11] Wang, C., Hao, L., Liu, C., Chen, R., Wang, W., Chen, Y., et al. (2020) Associations between Fine Particulate Matter Constituents and Daily Cardiovascular Mortality in Shanghai, China. Ecotoxicology and Environmental Safety, 191, Article ID: 110154. [Google Scholar] [CrossRef] [PubMed]
[12] 伍亚, 邹凤娟, 沈明辉, 等. 哈尔滨市大气PM2.5中五种金属成分复合暴露对人群死亡风险的影响[J]. 环境卫生学杂志, 2024, 14(9): 752-761.
[13] Lu, Y., Lin, S., Fatmi, Z., Malashock, D., Hussain, M.M., Siddique, A., et al. (2019) Assessing the Association between Fine Particulate Matter (PM2.5) Constituents and Cardiovascular Diseases in a Mega-City of Pakistan. Environmental Pollution, 252, 1412-1422. [Google Scholar] [CrossRef] [PubMed]
[14] 吴妍, 冯利红, 田瑛泽, 等. 2019-2020年天津市PM2.5组分与绿化环境暴露水平对缺血性脑卒中复发的时间序列分析研究[J]. 环境卫生学杂志, 2025, 15(7): 580-586.
[15] Zhang, Y., He, Q., Zhang, Y., Xue, X., Kan, H. and Wang, X. (2022) Differential Associations of Particle Size Ranges and Constituents with Stroke Emergency-Room Visits in Shanghai, China. Ecotoxicology and Environmental Safety, 232, Article ID: 113237. [Google Scholar] [CrossRef] [PubMed]
[16] Rodins, V., Lucht, S., Ohlwein, S., Hennig, F., Soppa, V., Erbel, R., et al. (2020) Long-Term Exposure to Ambient Source-Specific Particulate Matter and Its Components and Incidence of Cardiovascular Events—The Heinz Nixdorf Recall Study. Environment International, 142, Article ID: 105854. [Google Scholar] [CrossRef] [PubMed]
[17] Wang, W., Liu, C., Ying, Z., Lei, X., Wang, C., Huo, J., et al. (2019) Particulate Air Pollution and Ischemic Stroke Hospitalization: How the Associations Vary by Constituents in Shanghai, China. Science of the Total Environment, 695, Article ID: 133780. [Google Scholar] [CrossRef] [PubMed]
[18] Lv, S., Li, Z., Li, H., Liu, M., Wu, Z., Yu, S., et al. (2023) Long-Term Effects of PM2.5 Components on Hypertension: A National Analysis in China. Environmental Research, 222, Article ID: 115323. [Google Scholar] [CrossRef] [PubMed]
[19] Du, X., Zhang, Y., Liu, C., Fang, J., Zhao, F., Chen, C., et al. (2021) Fine Particulate Matter Constituents and Sub-Clinical Outcomes of Cardiovascular Diseases: A Multi-Center Study in China. Science of the Total Environment, 759, Article ID: 143555. [Google Scholar] [CrossRef] [PubMed]
[20] 哈里买买提∙那斯尔, 刘楠楠, 田家瑜, 等. 太原市大气PM2.5及其不同组分短期暴露对老年高血压患者血压的影响[J]. 环境卫生学杂志, 2023, 13(5): 363-370.
[21] 张丽. PM2.5及其组分与生活行为因素对高血压患者血压水平影响的交互作用研究[D]: [硕士学位论文]. 兰州: 兰州大学, 2023.
[22] Wang, J., Wu, S., Cui, J., Ding, Z., Meng, Q., Sun, H., et al. (2022) The Influences of Ambient Fine Particulate Matter Constituents on Plasma Hormones, Circulating TMAO Levels and Blood Pressure: A Panel Study in China. Environmental Pollution, 296, Article ID: 118746. [Google Scholar] [CrossRef] [PubMed]
[23] Fiordelisi, A., Piscitelli, P., Trimarco, B., Coscioni, E., Iaccarino, G. and Sorriento, D. (2017) The Mechanisms of Air Pollution and Particulate Matter in Cardiovascular Diseases. Heart Failure Reviews, 22, 337-347. [Google Scholar] [CrossRef] [PubMed]
[24] Lei, X., Chen, R., Wang, C., Shi, J., Zhao, Z., Li, W., et al. (2019) Personal Fine Particulate Matter Constituents, Increased Systemic Inflammation, and the Role of DNA Hypomethylation. Environmental Science & Technology, 53, 9837-9844. [Google Scholar] [CrossRef] [PubMed]
[25] Vivanco-Hidalgo, R.M., Wellenius, G.A., Basagaña, X., Cirach, M., González, A.G., Ceballos, P.d., et al. (2018) Short-term Exposure to Traffic-Related Air Pollution and Ischemic Stroke Onset in Barcelona, Spain. Environmental Research, 162, 160-165. [Google Scholar] [CrossRef] [PubMed]
[26] Yang, T., Chen, R., Gu, X., Xu, J., Yang, L., Zhao, J., et al. (2021) Association of Fine Particulate Matter Air Pollution and Its Constituents with Lung Function: The China Pulmonary Health Study. Environment International, 156, Article ID: 106707. [Google Scholar] [CrossRef] [PubMed]
[27] 王雅铮, 胡大宇, 贾旭, 等. 大气黑碳短期暴露与年轻健康个体肺功能和呼出气一氧化氮的关联研究[J]. 环境与健康杂志, 2020, 37(8): 673-677.
[28] Huang, S., Feng, H., Zuo, S., Liao, J., He, M., Shima, M., et al. (2019) Short-Term Effects of Carbonaceous Components in PM2.5 on Pulmonary Function: A Panel Study of 37 Chinese Healthy Adults. International Journal of Environmental Research and Public Health, 16, Article 2259. [Google Scholar] [CrossRef] [PubMed]
[29] 杨皓, 高绪芳, 鞠勇, 等. 成都市两监测点大气PM2.5污染及其离子成分对儿童肺功能的影响[J]. 环境与健康杂志, 2018, 35(12): 1051-1054.
[30] Zhou, L., Tao, Y., Li, H., Niu, Y., Li, L., Kan, H., et al. (2021) Acute Effects of Fine Particulate Matter Constituents on Cardiopulmonary Function in a Panel of COPD Patients. Science of the Total Environment, 770, Article ID: 144753. [Google Scholar] [CrossRef] [PubMed]
[31] Kobayashi, S., Yoda, Y., Takagi, H., Ito, T., Wakamatsu, J., Nakatsubo, R., et al. (2023) Short-Term Effects of the Chemical Components of Fine Particulate Matter on Pulmonary Function: A Repeated Panel Study among Adolescents. Science of the Total Environment, 895, Article ID: 165195. [Google Scholar] [CrossRef] [PubMed]
[32] Wang, Y., Shi, Z., Shen, F., Sun, J., Huang, L., Zhang, H., et al. (2019) Associations of Daily Mortality with Short-Term Exposure to PM2.5 and Its Constituents in Shanghai, China. Chemosphere, 233, 879-887. [Google Scholar] [CrossRef] [PubMed]
[33] Michikawa, T., Yamazaki, S., Ueda, K., Yoshino, A., Sugata, S., Saito, S., et al. (2021) Effects of Exposure to Chemical Components of Fine Particulate Matter on Mortality in Tokyo: A Case-Crossover Study. Science of the Total Environment, 755, Article ID: 142489. [Google Scholar] [CrossRef] [PubMed]
[34] 洪也, 张莹, 马雁军, 等. 沈阳市PM2.5离子成分对呼吸疾病门诊数影响研究[J]. 中国环境科学, 2018, 38(12): 4697-4705.
[35] 张媛媛. PM2.5组分暴露与呼吸系统疾病的关联研究[D]: [硕士学位论文]. 武汉: 武汉科技大学, 2022.
[36] Lavigne, É., Talarico, R., van Donkelaar, A., Martin, R.V., Stieb, D.M., Crighton, E., et al. (2021) Fine Particulate Matter Concentration and Composition and the Incidence of Childhood Asthma. Environment International, 152, Article ID: 106486. [Google Scholar] [CrossRef] [PubMed]
[37] 张晋. 母亲孕期PM2.5金属成分混合暴露对婴幼儿哮喘和喘息的影响[D]: [硕士学位论文]. 济南: 山东大学, 2024.
[38] El-Ghiaty, M.A. and El-Kadi, A.O.S. (2023) The Duality of Arsenic Metabolism: Impact on Human Health. Annual Review of Pharmacology and Toxicology, 63, 341-358. [Google Scholar] [CrossRef] [PubMed]
[39] 王雯静. 生命早期镉暴露增加小鼠过敏性哮喘的易感性[D]: [硕士学位论文]. 合肥: 安徽医科大学, 2023.

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