肺泡巨噬细胞在脓毒症合并ARDS中的作用机制及治疗潜力
The Mechanism of Action and Therapeutic Potential of Alveolar Macrophages in Sepsis Complicated with ARDS
DOI: 10.12677/acm.2026.161296, PDF,   
作者: 钟庆邦：赣南医科大学第一临床医学院，江西 赣州；朱宏泉*：赣南医科大学第一附属医院重症医学科，江西 赣州
关键词: 肺泡巨噬细胞；脓毒症；急性呼吸窘迫综合征；动态表型；精准分期；靶向治疗；Alveolar Macrophages； Sepsis； Acute Respiratory Distress Syndrome； Dynamic Phenotypes； Precise Staging； Targeted Therapy
摘要: 脓毒症合并急性呼吸窘迫综合征(ARDS)是一种相当严重的临床病症，它的特征是死亡率较高，给患者的诊疗工作给予了极大挑战，AMs属于肺免疫系统里的关键构成部分，对于维持肺免疫稳态以及调节炎症反应起着非常重要的作用。近年来，研究发现AMs的表型具有高度动态性，其变化不仅反映了疾病的进展状态，也为精准分期和个体化治疗提供了可能。不过当前对于AMs动态表型调控机制的理解并不全面，精准分期方法还处在探索时期，针对AMs的靶向治疗策略同样面临着临床转化的挑战。本文对AMs在脓毒症合并ARDS里的动态表型以及功能变化做了系统综述，剖析了基于AMs表型的精准分期方法，并且总结了当前靶向治疗策略及其临床应用前景，借助整合最新的基础研究成果与临床研究成果，推动脓毒症合并ARDS的精准诊疗进程，为改善患者预后提供理论支撑和治疗新思路。
Abstract: Sepsis combined with acute respiratory distress syndrome (ARDS) is a rather serious clinical condition, characterized by a high mortality rate, which poses a great challenge to the diagnosis and treatment of patients. Alveolar macrophages are a key component of the pulmonary immune system and play a very important role in maintaining pulmonary immune homeostasis and regulating inflammatory responses. In recent years, studies have found that the phenotype of alveolar macrophages is highly dynamic. Their changes not only reflect the progression status of the disease but also provide the possibility for precise staging and individualized treatment. However, the current understanding of the dynamic phenotypic regulatory mechanism of alveolar macrophages is not comprehensive. The precise staging method is still in the exploration stage, and the targeted treatment strategy for alveolar macrophages also faces the challenge of clinical transformation. This article systematically reviews the dynamic phenotypes and functional changes of alveolar macrophages in sepsis complicated with ARDS, analyzes the precise staging methods based on the phenotypes of alveolar macrophages, and summarizes the current targeted treatment strategies and their clinical application prospects. By integrating the latest basic research results and clinical research results, we can promote the precise diagnosis and treatment process of sepsis complicated with ARDS, and provide theoretical support and new treatment ideas for improving the prognosis of patients.
文章引用：钟庆邦, 朱宏泉. 肺泡巨噬细胞在脓毒症合并ARDS中的作用机制及治疗潜力[J]. 临床医学进展, 2026, 16(1): 2363-2373. https://doi.org/10.12677/acm.2026.161296

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