HIF-1α在PCOS中的机制研究及中医药干预的研究进展
Research Progress on the Mechanism of HIF-1α in PCOS and the Intervention of Traditional Chinese Medicine
DOI: 10.12677/acm.2026.161308, PDF,   
作者: 冯 璇：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨；沈文娟*：黑龙江中医药大学附属第一医院妇科三科，黑龙江 哈尔滨
关键词: 缺氧诱导因子-1α；多囊卵巢综合征；中医药；Hypoxia Inducible Factor-1α； Polycystic Ovary Syndrome； Traditional Chinese Medicine
摘要: 多囊卵巢综合征(PCOS)是一种常见的内分泌代谢疾病，其发病机制复杂，涉及胰岛素抵抗、高雄激素血症及慢性炎症等多重病理环节。缺氧诱导因子-1α (HIF-1α)作为缺氧应答关键因子，通过调控胰岛素信号、雄激素代谢、线粒体功能及炎症反应等多途径参与PCOS的发生发展。中药单体、中药复方可通过调控HIF-1α干预PCOS。通过对HIF-1α与PCOS的关系及中医药通过调控HIF-1α干预PCOS的研究进行总结，以期为PCOS临床治疗提供新思路。
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder. Its pathogenesis is complex and involves multiple pathological mechanisms such as insulin resistance, hyperandrogenemia, and chronic inflammation. Hypoxia inducible factor-1α (HIF-1α), a key regulator of hypoxic response, participates in the development and progression of PCOS through various pathways, including the regulation of insulin signaling, androgen metabolism, mitochondrial function, and inflammatory response. Both monomeric compounds and compound prescriptions of traditional Chinese medicine may exert therapeutic effects on PCOS by modulating HIF-1α. By reviewing the relationship between HIF-1α and PCOS, as well as research on TCM interventions that target HIF-1α, this article aims to provide new insights for the clinical management of PCOS.
文章引用：冯璇, 沈文娟. HIF-1α在PCOS中的机制研究及中医药干预的研究进展[J]. 临床医学进展, 2026, 16(1): 2463-2472. https://doi.org/10.12677/acm.2026.161308

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