脂质蓄积指数的相关研究进展及在认知中的作用：从流行病学到机制展望
Research Progress on Lipid Accumulation Product Index and Its Role in Cognition: From Epidemiology to Mechanism Perspectives
DOI: 10.12677/jcpm.2026.51071, PDF,   
作者: 刘 赟：山东第一医科大学附属省立医院神经内科，山东 济南
关键词: 脂质蓄积指数；痴呆；慢性炎症；胰岛素抵抗；Lipid Accumulation Product； Dementia； Chronic Inflammation； Insulin Resistance
摘要: 在人口老龄化加剧与全球痴呆疾病负担日益加重的背景下，针对可调控风险因素(如中心性肥胖)进行早期干预至关重要。脂质蓄积指数(lipid accumulation product, LAP)作为一种新兴的、综合反映内脏脂肪蓄积和脂代谢异常的简易指标，在社区痴呆风险筛查中展现出潜力。本文旨在系统综述目前LAP指数相关的研究进展，以及其通过慢性炎症与胰岛素抵抗影响认知功能的调节机制，以期为痴呆的早期预防与干预提供新思路。
Abstract: Against the backdrop of a rapidly aging population and the increasing global burden of dementia, early intervention targeting modifiable risk factors, particularly central obesity, has become critically important. The lipid accumulation product (LAP) index, an emerging composite indicator that reflects visceral adipose tissue accumulation and lipid metabolism, has shown promise as a simple tool for dementia risk screening in community settings. This review aims to summarize current advances in LAP-related research and to elucidate the underlying mechanisms involving chronic inflammation and insulin resistance through which LAP may influence cognitive function, thereby providing insights for early prevention and intervention strategies for dementia.
文章引用：刘赟. 脂质蓄积指数的相关研究进展及在认知中的作用：从流行病学到机制展望[J]. 临床个性化医学, 2026, 5(1): 514-520. https://doi.org/10.12677/jcpm.2026.51071

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