肩袖腱–骨愈合在组织工程学领域的研究进展
Study Advances in Rotator Cuff Tend-Bone Healing in the Field of Tissue Engineering
DOI: 10.12677/jcpm.2026.51074, PDF,    科研立项经费支持
作者: 尚茂玮, 查方景, 赵敏捷, 吴嘉仪, 陈 诺：南京中医药大学常州附属医院，江苏 常州；杨建平*：常州市中医医院骨科，江苏 常州
关键词: 肩袖损伤；腱–骨愈合；组织工程学；间充质干细胞；生物材料；低氧浓度环境；Rotator Cuff Injury； Tendon-Bone Healing； Tissue Engineering； Mesenchymal Stem Cell； Biomaterials； Low-Oxygen Concentration Environment
摘要: 肩袖损伤后腱–骨界面原有组织遭到破坏，大量纤维瘢痕组织新生填充，腱骨界面缺失组成、结构以及力学等自身固有的典型移行渐变性特征，造成应力过于集中、界面失效，引发肩袖再撕裂。目前，种子细胞、支架和生物活性分子的三维修复方式是组织工程技术不断发展的方向。因此，深入了解腱–骨界面结构组成及其修复过程发生机制，积极寻找促进腱–骨愈合的组织工程学技术改善肩袖损伤疗效至关重要。基于目前对于腱–骨愈合的认识，本文拟对近年来组织工程技术在促进肩袖腱骨愈合方面的研究进展予以系统综述与归纳总结，旨在增进临床医务人员对肩袖损伤病理学机制的深入理解，以期为肩袖损伤的临床诊疗提供新颖的治疗策略与思路。
Abstract: In the aftermath of a rotator cuff injury, the initial tissues comprising the tendon-bone interface undergo destruction, giving rise to the formation of substantial fibrous scar tissue. The tendon-bone interface is characterized by a lack of inherent composition, structure, and mechanics. These characteristics are typically associated with processes of migration and gradual change. Currently, the three-dimensional repair approach involving seed cells, scaffolds, and bioactive molecules represents the evolving direction of tissue engineering technology. The field of tissue engineering technology is undergoing continuous development, with a focus on three-dimensional repair methodologies that utilize seed cells, scaffolds, and bioactive molecules. Therefore, it is imperative to comprehend the structural composition of the tendon-bone interface and the mechanism of its repair process. Moreover, there is an active need to search for tissue engineering techniques to promote tendon-bone healing to improve the efficacy of rotator cuff injuries. Based on current understanding of tendon-bone healing, this paper aims to provide a systematic review and summary of recent research progress in tissue engineering techniques for promoting rotator cuff tendon-bone healing. The objective is to enhance clinical practitioners’ understanding of the pathological mechanisms underlying rotator cuff injuries, thereby offering novel therapeutic strategies and insights for the clinical diagnosis and treatment of such injuries.
文章引用：尚茂玮, 杨建平, 查方景, 赵敏捷, 吴嘉仪, 陈诺. 肩袖腱–骨愈合在组织工程学领域的研究进展[J]. 临床个性化医学, 2026, 5(1): 537-545. https://doi.org/10.12677/jcpm.2026.51074

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