中西医结合方法修复溃疡性结肠炎患者肠黏膜屏障的研究进展

Research Progress on Repairing the Intestinal Mucosal Barrier in Patients with Ulcerative Colitis by Integration of Traditional and Western Medicine Method

摘要: 溃疡性结肠炎(UC)是一种慢性、非特异性炎症性肠病，临床表现为腹痛、腹泻、粘液脓血便等，具有缓解期和活动期交替的特点，常迁延难愈。肠黏膜屏障功能障碍是导致UC发病的重要机制之一。近年来中西医结合方法修复溃疡性结肠炎患者肠黏膜屏障的临床研究日益增多，同时促进肠黏膜愈合，减轻炎症反应，调节肠道菌群，调节免疫功能，减轻氧化应激反应等。本文综述中西医结合修复溃疡性结肠炎患者肠黏膜屏障的临床方法和效果进展。

Abstract: Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease. Its clinical manifestations include abdominal pain, diarrhea, mucopurulent bloody stools, etc. It is characterized by the alternation of remission and active periods and often has a protracted course. Impairment of the intestinal mucosal barrier function is one of the important mechanisms leading to the onset of UC. In recent years, there has been an increasing number of clinical studies on the repair of the intestinal mucosal barrier in patients with ulcerative colitis using the integrated traditional Chinese and Western medicine approach. This approach can promote the healing of the intestinal mucosa, alleviate the inflammatory response, regulate the intestinal flora, modulate the immune function, and reduce the oxidative stress response. This paper reviews the progress in the clinical methods and effects of the integrated traditional Chinese and Western medicine in repairing the intestinal mucosal barrier of patients with ulcerative colitis.