非O1/非O139群霍乱弧菌研究进展：流行病学、致病机制与防控策略

Research Progress on Non-O1/Non-O139 Vibrio cholerae: Epidemiology, Pathogenesis, and Prevention and Control Strategies

摘要: 非O1/非O139群霍乱弧菌(non-O1/non-O139 Vibrio cholerae，简称NOVC)是一类不携带霍乱毒素基因簇的霍乱弧菌，与可引发典型霍乱的产毒型O1/O139群在致病机制上具有根本区别。近年来，NOVC作为一种重要的水生致病菌，其所致感染病例在全球范围内呈逐渐增多趋势。本文系统阐述NOVC在流行病学、毒力因子、致病机制、鉴定技术、耐药性及临床防治策略等方面的最新研究进展，以期为该类感染的临床诊治与公共卫生监测提供科学依据。

Abstract: Non-O1/non-O139 Vibrio cholerae (NOVC) refers to a group of Vibrio cholerae strains that do not carry the cholera toxin gene cluster, which fundamentally distinguishes them in pathogenic mechanism from the toxigenic O1/O139 strains classically associated with epidemic cholera. In recent years, NOVC has become a significant aquatic pathogen, and the number of human infections caused by it has been increasing globally. This article systematically reviews the latest research advances in NOVC, covering its epidemiology, virulence factors, pathogenic mechanisms, identification techniques, antimicrobial resistance, and clinical prevention and treatment strategies, with the aim of providing a scientific basis for clinical management and public health surveillance of such infections.