血浆致动脉粥样硬化指数与冠心病相关性研究进展及其作为预测指标的优势与局限
Research Progress on the Association between AIP and the Risk of Coronary Heart Disease Onset, as Well as Its Advantages and Limitations as a Predictive Indicator
DOI: 10.12677/acm.2026.162364, PDF,   
作者: 高诗惠：成都中医药大学医学与生命科学学院，四川 成都；淡雪川：宜宾市第二人民医院心血管内科，四川 宜宾
关键词: 冠心病；血脂；血浆致动脉粥样硬化指数；Coronary Heart Disease； Lipid； Atherogenic Index of Plasma
摘要: 冠状动脉粥样硬化性心脏病(coronary heart disease, CHD)的发病机制与脂质沉积形成粥样斑块致血管狭窄或闭塞相关，血浆致动脉粥样硬化指数(atherogenic index of plasma, AIP)作为新型血脂代谢综合指标，在反映脂质代谢状态、评估抗动脉粥样硬化潜力方面优于传统血脂指标，为冠心病风险评估提供重要参考。然而，其临床应用仍面临局限：易受多种生理和病理因素的干扰，且与其他生物标志物联合应用的适配性仍存在争议。本文旨在探讨AIP与冠心病发生发展的关联机制，剖析其作为预测指标的优势与局限，为未来的研究方向提供有益见解，以推进临床应用发展，为冠心病的早期预防、精准评估及临床决策提供更具价值的理论依据。
Abstract: The pathogenesis of coronary heart disease (CHD) is linked to vascular stenosis or occlusion caused by atherosclerotic plaque formation secondary to lipid deposition. As a novel lipid indicator, the plasma atherogenic index (AIP) demonstrates superior efficacy compared to traditional lipid markers in reflecting lipid metabolism status and anti-atherosclerotic capacity, providing a crucial reference for CHD risk assessment. However, its clinical application faces limitations, including susceptibility to various physiological and pathological factors, as well as controversies regarding its compatibility when combined with other biomarkers. This study aims to investigate the underlying mechanisms linking AIP to the onset and progression of CAD, critically analyzing its advantages and limitations as a predictive marker. By doing so, we aim to provide valuable insights for future research directions, thereby advancing clinical applications and offering robust theoretical foundations for the early prevention, precise assessment, and clinical decision-making regarding CAD.
文章引用：高诗惠, 淡雪川. 血浆致动脉粥样硬化指数与冠心病相关性研究进展及其作为预测指标的优势与局限[J]. 临床医学进展, 2026, 16(2): 84-92. https://doi.org/10.12677/acm.2026.162364

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