针刺调控相关信号通路防治帕金森病的研究进展
Research Progress on Acupuncture Regulation of Related Signaling Pathways in the Prevention and Treatment of Parkinson’s Disease
DOI: 10.12677/acm.2026.162381, PDF,   
作者: 牛璐瑶：黑龙江省中医药科学院，黑龙江 哈尔滨；王 顺*：黑龙江中医药大学第二临床医学院，黑龙江 哈尔滨
关键词: 针刺；帕金森病；信号通路；研究进展；Acupuncture； Parkinson’s Disease； Signal Pathway； Research Progress
摘要: 帕金森病(PD)是中老年人最常见的疾病之一，因其早期症状不明显，起病隐匿，极易被漏诊和误诊，晚期甚至会出现自主神经功能紊乱、睡眠障碍、抑郁和痴呆等，对中老年人的生活质量产生重大影响。最新研究表明，PD的病理变化与细胞凋亡相关信号通路的异常激活和炎症有关。大量针刺治疗PD的动物和临床研究表明，调控PI3K/Akt、NF-κB、JNK、NLRP3等信号通路是针刺治疗PD的重要靶点。大多数针对PD的常规治疗干预措施效果有限，并且具有严重的副作用，本文就帕金森相关信号通路及针刺调控作用展开综述，以期为针刺防治PD的机制作用提供理论依据，并为今后深入的研究提供参考。
Abstract: Parkinson’s disease (PD) is one of the most common diseases among middle-aged and elderly people. Due to its unclear early symptoms, insidious onset, and easy misdiagnosis, it can even lead to autonomic nervous system dysfunction, sleep disorders, depression, and dementia in the later stages, which have a significant impact on the quality of life of middle-aged and elderly people. The latest research shows that the pathological changes of Parkinson’s disease are related to abnormal activation of apoptosis related signaling pathways and inflammation. Numerous animal and clinical studies on acupuncture treatment for PD have shown that regulating signaling pathways such as PI3K/Akt, NF-κB, JNK, and NLRP3 is an important target for acupuncture treatment of PD. Most conventional treatment interventions for Parkinson’s disease have limited effectiveness and serious side effects. This article provides a review of Parkinson’s related signaling pathways and acupuncture regulation, in order to provide theoretical basis for the mechanism and role of acupuncture in preventing and treating Parkinson’s disease, and to provide reference for future in-depth research.
文章引用：牛璐瑶, 王顺. 针刺调控相关信号通路防治帕金森病的研究进展[J]. 临床医学进展, 2026, 16(2): 209-216. https://doi.org/10.12677/acm.2026.162381

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