妊娠期缺铁性贫血的研究现状与突破
The Current State and Breakthroughs in Research on Iron Deficiency Anemia during Pregnancy
摘要: 妊娠期贫血一直是共同关注的话题,也是孕期最常见的并发症之一,以缺铁性贫血最常见,是严重影响母婴健康的重要公共卫生问题。贫血对母儿健康均可造成不良影响,如增加妊娠期高血压、产后出血、产褥感染的风险,以及导致胎儿生长受限、早产、低出生体重儿,甚至对后代的神经发育产生负面影响。当前全球贫血的诊断标准存在争议,对妊娠结局的影响和补铁策略存在分歧。本文系统综述了妊娠期贫血的流行病学特征、病理生理机制、诊断方法、对母婴的影响以及临床管理策略及预防措施。通过对现有文献的综合分析,旨在为临床工作者提供最新的理论和实践指导,以改善母婴预后。
Abstract: Anemia during pregnancy remains a subject of shared clinical concern and represents one of the most prevalent complications in gestation, with iron-deficiency anemia being the most common subtype. It constitutes a significant public health issue that severely impacts maternal and infant health outcomes. Anemia adversely affects both maternal and fetal well-being, increasing the risks of gestational hypertension, postpartum hemorrhage, puerperal infections, as well as contributing to fetal growth restriction, preterm birth, low birth weight, and even negative impacts on offspring neuro development. Current global diagnostic criteria for anemia remain contentious, with ongoing debates regarding its influence on pregnancy outcomes and iron supplementation strategies. This article provides a systematic review of the epidemiological characteristics, pathophysiological mechanisms, diagnostic approaches, maternal and fetal consequences, clinical management strategies, and preventive measures for gestational anemia. Through a comprehensive analysis of existing literature, it aims to offer updated theoretical and practical guidance for healthcare practitioners to improve maternal and neonatal prognoses.
文章引用:卢妍, 贺译平, 魏君香, 陈偲敏, 王心如, 刘一迪. 妊娠期缺铁性贫血的研究现状与突破[J]. 医学诊断, 2026, 16(1): 58-65. https://doi.org/10.12677/md.2026.161009

参考文献

[1] Stevens, G.A., Paciorek, C.J., Flores-Urrutia, M.C., Borghi, E., Namaste, S., Wirth, J.P., et al. (2022) National, Regional, and Global Estimates of Anaemia by Severity in Women and Children for 2000-19: A Pooled Analysis of Population-Representative Data. The Lancet Global Health, 10, e627-e639. [Google Scholar] [CrossRef] [PubMed]
[2] Stevens, G.A., Finucane, M.M., De-Regil, L.M., Paciorek, C.J., Flaxman, S.R., Branca, F., et al. (2013) Global, Regional, and National Trends in Haemoglobin Concentration and Prevalence of Total and Severe Anaemia in Children and Pregnant and Non-Pregnant Women for 1995-2011: A Systematic Analysis of Population-Representative Data. The Lancet Global Health, 1, e16-e25. [Google Scholar] [CrossRef] [PubMed]
[3] Karpova, N., Dmitrenko, O., Arshinova, E. and Nurbekov, M. (2025) Polymorphism rs259983 of the ZNF831 Gene Is Associated with the Risk of Anemia in Pregnant Women with Gestational Diabetes. Egyptian Journal of Medical Human Genetics, 26, Article No. 94. [Google Scholar] [CrossRef] [PubMed]
[4] Al-Taiar, A., Ziyab, A.H., Hammoud, M.S., Al-Sabah, R. and Akhtar, S. (2025) Anemia in Pregnant Women: Findings from Kuwait Birth Cohort Study. BMC Pregnancy and Childbirth, 25, Article No. 326. [Google Scholar] [CrossRef] [PubMed]
[5] Karami, M., Chaleshgar, M., Salari, N., Akbari, H. and Mohammadi, M. (2022) Global Prevalence of Anemia in Pregnant Women: A Comprehensive Systematic Review and Meta-Analysis. Maternal and Child Health Journal, 26, 1473-1487. [Google Scholar] [CrossRef] [PubMed]
[6] 杨林, 王亦雄, 潘辉, 等. 妊娠晚期缺铁性贫血的危险因素和列线图预测模型[J]. 中山大学学报(医学科学版), 2025, 46(1): 116-122.
[7] Sun, M., Gu, T., Wu, T., Gong, X., Li, X., Huang, J., et al. (2023) Variation Patterns of Hemoglobin Levels by Gestational Age during Pregnancy: A Cross-Sectional Analysis of a Multi-Center Retrospective Cohort Study in China. Nutrients, 15, Article 1383. [Google Scholar] [CrossRef] [PubMed]
[8] 赵思宇, 景文展, 刘珏, 等. 中国妇女2012-2016年妊娠期贫血患病状况的Meta分析[J]. 中华预防医学杂志, 2018, 52(9): 951-957.
[9] Zhou, Y., Lyu, Y., Ye, W., Shi, H., Peng, Y., Wen, Z., et al. (2024) The Prevalence of Anemia among Pregnant Women in China: A Systematic Review and Meta-Analysis. Nutrients, 16, Article 1854. [Google Scholar] [CrossRef] [PubMed]
[10] World Health Organization (2011) Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity.
[11] Garcia‐Casal, M.N., Pasricha, S., Sharma, A.J. and Peña‐Rosas, J.P. (2019) Use and Interpretation of Hemoglobin Concentrations for Assessing Anemia Status in Individuals and Populations: Results from a WHO Technical Meeting. Annals of the New York Academy of Sciences, 1450, 5-14. [Google Scholar] [CrossRef] [PubMed]
[12] Auerbach, M., Abernathy, J., Juul, S., Short, V. and Derman, R. (2021) Prevalence of Iron Deficiency in First Trimester, Nonanemic Pregnant Women. The Journal of Maternal-Fetal & Neonatal Medicine, 34, 1002-1005. [Google Scholar] [CrossRef] [PubMed]
[13] 程雨露, 王小新, 邹丽颖. 妊娠期铁缺乏及缺铁性贫血的诊疗[J]. 中华全科医师杂志, 2024, 23(9): 1007-1010.
[14] 中华医学会血液学分会红细胞疾病(贫血)学组. 铁缺乏症和缺铁性贫血诊治和预防的多学科专家共识(2022年版) [J]. 中华医学杂志, 2022, 102(41): 3246-3256.
[15] Peyrin-Biroulet, L., Williet, N. and Cacoub, P. (2015) Guidelines on the Diagnosis and Treatment of Iron Deficiency across Indications: A Systematic Review. The American Journal of Clinical Nutrition, 102, 1585-1594. [Google Scholar] [CrossRef] [PubMed]
[16] Shi, H., Chen, L., Wang, Y., Sun, M., Guo, Y., Ma, S., et al. (2022) Severity of Anemia during Pregnancy and Adverse Maternal and Fetal Outcomes. JAMA Network Open, 5, e2147046. [Google Scholar] [CrossRef] [PubMed]
[17] 徐蕾, 邓晓杨. 早期检测及干预铁缺乏对妊娠期缺铁性贫血影响的研究[J]. 标记免疫分析与临床, 2017, 24(1): 45-47.
[18] 何国琳, 孙鑫, 谭婧, 等. 中国部分城市妊娠期铁缺乏和缺铁性贫血患病率的调查[J]. 中华妇产科杂志, 2018, 53(11): 761-767.
[19] Huang, N., Zhuang, J., Wang, Y., et al. (2025) Screening Efficacy of Erythroferrone and Hepcidin in Identifying Thalassemia with Iron-Deficiency Anemia among Pregnant Women. Scandinavian Journal of Clinical and Laboratory Investigation, 85, 444-451.
[20] Wolff, F., De Breucker, S., Pepersack, T., Compté, N., Mélot, C., Gulbis, B., et al. (2019) Baseline Hepcidin Measurement in the Differential Diagnosis of Anaemia for Elderly Patients and Its Correlation with the Increment of Transferrin Saturation Following an Oral Iron Absorption Test. Clinical Chemistry and Laboratory Medicine (CCLM), 57, 250-258. [Google Scholar] [CrossRef] [PubMed]
[21] Nemeth, E. and Ganz, T. (2021) Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis. International Journal of Molecular Sciences, 22, Article 6493. [Google Scholar] [CrossRef] [PubMed]
[22] Okashita, N., Maeda, R., Kuroki, S., Sasaki, K., Uno, Y., Koopman, P., et al. (2025) Maternal Iron Deficiency Causes Male-to-Female Sex Reversal in Mouse Embryos. Nature, 643, 262-270. [Google Scholar] [CrossRef] [PubMed]
[23] Yadav, D.V., Mitra, T., Punniyamoorthy, D., Murugesan, A., Kumari Raveendran, S. and Janardhanan, R. (2025) Vitamins and Iron-Deficiency Gestational Anemia—A Review. Journal of Dietary Supplements, 22, 887-906. [Google Scholar] [CrossRef
[24] Pavord, S., Daru, J., Prasannan, N., Robinson, S., Stanworth, S. and Girling, J. (2020) UK Guidelines on the Management of Iron Deficiency in Pregnancy. British Journal of Haematology, 188, 819-830. [Google Scholar] [CrossRef] [PubMed]
[25] Troike, K.M. and McShane, A.J. (2025) Re-Evaluating Ferritin Thresholds to Diagnose Iron Deficiency. Clinical Biochemistry, 140, Article ID: 111020. [Google Scholar] [CrossRef
[26] Kriel, M., Opie, J., Rusch, J., Richardson, D. and Louw, V. (2025) Old Tests and New Paradigms: How to Interpret Iron Studies and Related Biomarkers for the Diagnosis of Iron Deficiency in Adults. Blood Reviews, 74, Article ID: 101337. [Google Scholar] [CrossRef
[27] Ratnaningsih, T., Martani, G.R., Putri, D.C. and Sukorini, U. (2025) Schistocytes Evaluation in Iron Deficiency: An Assessment Adopted from ICSH Nomenclature Guideline. Anemia, 2025, Article ID: 9990762. [Google Scholar] [CrossRef] [PubMed]
[28] 陆甜甜, 莫伟明, 施国美. 红细胞参数计算公式+红细胞形态学积分在地中海贫血和缺铁性贫血中的鉴别价值[J]. 中华地方病学杂志, 2025, 44(2): 106-111.
[29] Hansen, R., Kurtzhals, J., Styrishave, B. and Holm, C. (2021) Baseline Hepcidin Does Not Predict the Response to Iron Therapy in Pregnant Women with Iron Deficiency. Blood, 138, 3076. [Google Scholar] [CrossRef
[30] Markovic, M., Majkic-Singh, N., Subota, V., et al. (2004) Reticulocyte Hemoglobin Content in the Diagnosis of Iron Deficiency Anemia. Clinical Laboratory, 50, 431-436.
[31] Neef, V., Schmitt, E., Bader, P., Zierfuß, F., Hintereder, G., Steinbicker, A.U., et al. (2021) The Reticulocyte Hemoglobin Equivalent as a Screening Marker for Iron Deficiency and Iron Deficiency Anemia in Children. Journal of Clinical Medicine, 10, Article 3506. [Google Scholar] [CrossRef] [PubMed]
[32] 卢光莉, 周翔, 孔德仁, 等. 贫血与产后抑郁关系的Meta分析[J]. 中国心理卫生杂志, 2021, 35(5): 382-388.
[33] 李哲玮. 妊娠合并缺铁性贫血对母婴结局影响的循证评价与回顾性研究[D]: [硕士学位论文]. 兰州: 兰州大学, 2025.
[34] 单雅娟. 海岛地区孕妇妊娠晚期铁蛋白与甲状腺功能的关系的回顾[D]: [硕士学位论文]. 杭州: 浙江中医药大学, 2023.
[35] 史志平, 丰暖, 刘晓宁, 等. 妊娠早期贫血和甲状腺功能减退的相关性研究[J]. 肠外与肠内营养, 2025, 32(3): 142-145.
[36] 倪爱青, 何大强, 杨金军. 妊娠期糖尿病患者孕期甲状腺功能和贫血指标的变化及与母婴结局的相关性[J]. 中国妇幼保健, 2022, 37(2): 193-196.
[37] Beckert, R.H., Baer, R.J., Anderson, J.G., Jelliffe-Pawlowski, L.L. and Rogers, E.E. (2019) Maternal Anemia and Pregnancy Outcomes: A Population-Based Study. Journal of Perinatology, 39, 911-919. [Google Scholar] [CrossRef] [PubMed]
[38] Wiegersma, A.M., Dalman, C., Lee, B.K., Karlsson, H. and Gardner, R.M. (2019) Association of Prenatal Maternal Anemia with Neurodevelopmental Disorders. JAMA Psychiatry, 76, 1294-1304. [Google Scholar] [CrossRef] [PubMed]
[39] 曾悦, 何国琳. 妊娠期预防性补铁的研究进展[J]. 现代妇产科进展, 2023, 32(6): 458-460.
[40] 梁玲. 妊娠期预防性补铁时机的选择及其对妊娠结局的影响[J]. 实用妇科内分泌电子杂志, 2020, 7(26): 54-55.
[41] Abioye, A.I., Hughes, M.D., Sudfeld, C.R., Premji, Z., Aboud, S., Hamer, D.H., et al. (2023) The Effect of Iron Supplementation on Maternal Iron Deficiency Anemia Does Not Differ by Baseline Anemia Type among Tanzanian Pregnant Women without Severe Iron Deficiency Anemia. European Journal of Nutrition, 62, 987-1001. [Google Scholar] [CrossRef] [PubMed]
[42] Zhou, M., Song, L., Huang, Y. and Chen, D. (2025) Associations between Serum Ferritin Levels and Gestational Diabetes Mellitus among a Non-Anemic Population. BMC Pregnancy and Childbirth, 25, Article No. 288. [Google Scholar] [CrossRef] [PubMed]
[43] 赵静, 丁虹娟. 3种铁剂治疗妊娠中期缺铁性贫血的费效分析及对妊娠结局和新生儿铁储备的影响[J]. 西北药学杂志, 2025, 40(6): 233-239.
[44] 陈舞燕. 多糖铁复合物与琥珀酸亚铁用于预防高龄孕妇孕中期缺铁性贫血的成本-效果分析[J]. 中国现代药物应用, 2019, 13(7): 164-165.
[45] 王晓芳, 王芙蓉. 健脾生血颗粒联合琥珀酸亚铁治疗妊娠期缺铁性贫血患者的效果[J]. 中外医学研究, 2025, 23(1): 19-22.
[46] 李兆琪. 不同频率、剂量的口服铁剂对治疗妊娠期缺铁性贫血的影响[D]: [硕士学位论文]. 济南: 山东大学, 2024.
[47] 孙丽颖. 不同治疗方式在妊娠期贫血中的应用进展[J]. 中国城乡企业卫生, 2023, 38(8): 24-26.
[48] Burwick, R. and Govindappagari, S. (2018) Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis. American Journal of Perinatology, 36, 366-376. [Google Scholar] [CrossRef] [PubMed]