阻塞性睡眠呼吸暂停综合征的代谢影响及其治疗进展
Metabolic Effects and Treatment Progress of Obstructive Sleep Apnea Syndrome
DOI: 10.12677/acm.2026.162402, PDF,   
作者: 吕智勇：重庆医科大学附属第二医院内科，重庆；黄 晶*：重庆医科大学附属第二医院心血管内科，重庆
关键词: 阻塞性睡眠呼吸暂停综合征；高血压；治疗进展；Obstructive Sleep Apnea Syndrome； Hypertension； Treatment Progress
摘要: 阻塞性睡眠呼吸暂停综合征(Obstructive Sleep Apnea Syndrome, OSAS)是一种常见的睡眠呼吸障碍，其特征是睡眠期间反复发生的上气道部分或完全塌陷，从而导致间歇性低氧(IH)和睡眠片段化(SF)。近年来，越来越多的研究表明，OSAS与代谢紊乱密切相关，包括胰岛素抵抗、肥胖、血脂异常、高血压等代谢综合征。本文综述了OSAS影响代谢的病理生理机制，包括氧化应激、炎症反应、交感神经激活等，并探讨了持续气道正压通气(CPAP)等治疗手段对代谢的改善作用。
Abstract: Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep breathing disorder characterized by repeated partial or complete collapse of the upper airway during sleep, which leads to Intermittent Hypoxia (IH) and Sleep Fragmentation (SF). In recent years, an increasing number of studies have shown that OSAS is closely related to metabolic disorders, including insulin resistance, obesity, dyslipidemia, hypertension and other metabolic syndromes. This article reviews the pathophysiological mechanisms by which OSAS affects metabolism, including oxidative stress, inflammatory response, sympathetic nerve activation, etc., and explores the improvement effects of treatment methods such as Continuous Positive Airway Pressure ventilation (CPAP) on metabolism.
文章引用：吕智勇, 黄晶. 阻塞性睡眠呼吸暂停综合征的代谢影响及其治疗进展[J]. 临床医学进展, 2026, 16(2): 365-372. https://doi.org/10.12677/acm.2026.162402

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