HA380在治疗高脂血症性胰腺炎中的疗效与预后分析
Analysis of Curative Effect and Prognosis of HA380 in the Treatment of Hyperlipidemia Pancreatitis
DOI: 10.12677/jcpm.2026.51088, PDF,    科研立项经费支持
作者: 吴 涛, 石晓旭, 张盼盼, 李立伟, 夏 翔：鹤壁市人民医院急诊科，河南 鹤壁；张 斌：青海省人民医院急诊科，青海 西宁
关键词: HA380；双重滤过血浆置换；高脂血症性胰腺炎；疗效；HA380； Double Filtration Plasma Exchange； Hyperlipidemic Pancreatitis； Curative Effect
摘要: 目的：本研究旨在评估血液灌流器HA380在治疗高脂血症性胰腺炎(HLAP)中的疗效和预后，以期为临床治疗HLAP提供更多治疗选择。方法：根据严格的纳入和排除标准，我们收集2023年8月至2024年10月期间在青海省人民医院接受双重滤过血浆置换(DFPP)治疗和鹤壁市人民医院使用HA380治疗的HLAP患者共44例，并将他们分为DFPP组(n = 23)和HA380组(n = 21)。通过比较治疗前后两组患者的血脂、淀粉酶、炎症指标和生命体征等指标，分析HA380和DFPP治疗HLAP的疗效。结果：HA380组在降低甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)和血清淀粉酶(AMY)方面，治疗前后差异有统计学意义(P ≤ 0.05)；DFPP组在降低TG、TC、HDL-C、LDL-C、AMY、降钙素原(PCT)和白细胞(WBC)方面，治疗前后差异也有统计学意义(P < 0.05)。然而，两组间比较显示，所有指标差异无统计学意义(P > 0.05)。结论：HA380和DFPP两种血液净化模式均能有效降低HLAP患者的血脂水平和炎症介质。
Abstract: Objective: The purpose of this study is to evaluate the curative effect and prognosis of hemoperfusion device HA380 in the treatment of hyperlipidemia pancreatitis (HLAP), so as to provide more treatment options for clinical treatment of HLAP. Methods: According to strict inclusion and exclusion criteria, we collected 44 cases of HLAP patients who were treated with double filtered plasma exchange (DFPP) in Qinghai People’s Hospital and HA380 in Hebi People’s Hospital from August 2023 to October 2024, and divided them into DFPP group (n = 23) and HA380 group (n = 21). By comparing the blood lipid, amylase, inflammatory index and vital signs of the two groups before and after treatment, the curative effect of HA380 and DFPP on HLAP was analyzed. Results: In the HA380 group, the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and serum amylase (AMY) were significantly decreased before and after treatment (P ≤ 0.05). The levels of TG, TC, HDL-C, LDL-C, AMY, procalcitonin (PCT) and white blood cells (WBC) in DFPP group were also significantly lower before and after treatment (P < 0.05). However, the comparison between the two groups showed that there was no significant difference in all indicators (P > 0.05). Conclusion: HA380 and DFPP can effectively reduce the blood lipid level and inflammatory mediators in patients with HLAP.
文章引用：吴涛, 石晓旭, 张盼盼, 李立伟, 夏翔, 张斌. HA380在治疗高脂血症性胰腺炎中的疗效与预后分析[J]. 临床个性化医学, 2026, 5(1): 652-658. https://doi.org/10.12677/jcpm.2026.51088

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