TG主要衍生代谢指数与糖尿病患者并发冠心病关系的研究进展
Research Progress on the Relationship between Major Triglyceride-Derived Metabolic Indices and Coronary Artery Disease Complicating Diabetes Mellitus
DOI: 10.12677/acm.2026.162408, PDF,   
作者: 井 淼：西安医学院研究生院，陕西 西安；严琴琴：西安医学院全科医学研究所，陕西 西安；张 蓓：西安医学院第一附属医院神经内科，陕西 西安；吴 江：西安市韩森寨社区卫生服务中心，陕西 西安
关键词: 糖尿病；冠心病；甘油三酯–葡萄糖指数；Diabetes Mellitus； Coronary Artery Disease； Triglyceride-Glucose Index
摘要: 冠状动脉粥样硬化性心脏病(冠心病)是全球范围内严重威胁人类健康的慢性疾病之一。随着生活水平的提高，其常见危险因素之一——糖尿病的发病率——也逐年升高。胰岛素抵抗与糖尿病和冠心病的发生、发展密切相关。甘油三酯(TG)是主要衍生代谢指数，包括甘油三酯–葡萄糖指数(TyG)、动脉粥样硬化指数(AIP)及甘油三酯–葡萄糖–体重指数(TyG-BMI)，作为反映脂质代谢紊乱和胰岛素抵抗的新型综合指标，近年来在糖尿病患者并发冠心病的风险评估中备受关注。文章归纳总结胰岛素抵抗在糖尿病患者并发冠心病中的病理生理机制，以及TG主要衍生代谢指数(TyG, AIP, TyG-BMI)与糖尿病患者并发冠心病之间的关系。
Abstract: Coronary atherosclerotic heart disease (CAD) is one of the chronic conditions that poses a grave threat to human health worldwide. Concurrently, as living standards improved, the incidence of diabetes mellitus—a key risk factor for CAD—had risen steadily. Insulin resistance (IR) was recognized as playing a central role in the pathogenesis and progression of both diabetes and CAD. Several triglyceride (TG)-derived metabolic indices, including the triglyceride-glucose (TyG) index, the atherogenic index of plasma (AIP), and the triglyceride-glucose-body mass index (TyG-BMI), have emerged as integrated surrogate markers of dyslipidemia and IR. These indices had attracted considerable interest for their potential in risk stratification of CAD among diabetic patients. This article summarizes the pathophysiological mechanisms of insulin resistance in diabetic patients complicated with coronary heart disease, as well as the relationship between triglyceride‑related derivative metabolic indices (TyG, AIP, TyG‑BMI) and the occurrence of coronary heart disease in diabetic patients.
文章引用：井淼, 严琴琴, 张蓓, 吴江. TG主要衍生代谢指数与糖尿病患者并发冠心病关系的研究进展[J]. 临床医学进展, 2026, 16(2): 410-418. https://doi.org/10.12677/acm.2026.162408

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