孟德尔随机化在衰弱相关研究中的应用
Application of Mendelian Randomization in Frailty-Related Research
DOI: 10.12677/acm.2026.162421, PDF,    科研立项经费支持
作者: 黄丽娟：西安医学院第一附属医院全科医学科，陕西 西安；王敏娟*：西安医学院第三附属医院全科医学科，陕西 西安
关键词: 衰弱；孟德尔随机化；生活行为方式；疾病；生物标志物；Frailty； Mendelian Randomization； Lifestyle Behaviors； Diseases； Biomarkers
摘要: 随着全球人口老龄化进程的加速，衰弱已成为影响老年人健康的重要公共卫生问题，而传统观察性研究因混杂偏倚和反向因果限制难以阐明其确切病因，孟德尔随机化为病因探究提供了新途径。该研究系统回顾了近年来以衰弱为结局指标的孟德尔随机化研究进展，着重介绍了此方法在生活行为方式(吸烟、饮酒、睡眠特征、饮食、体育活动)、疾病(心脏代谢疾病、炎症性肠病、抑郁)及生物标志物(肠道微生物、血脂)等暴露因素与衰弱因果关系验证中的应用，丰富了衰弱的致病因素和防治思路，为后续临床和公共卫生决策提供了理论依据。
Abstract: With the accelerating pace of global population aging, frailty has become a critical public health issue affecting the health of older adults. Traditional observational studies are limited by confounding bias and reverse causality, making it difficult to elucidate its exact etiology. Mendelian Randomization (MR) provides a novel approach for etiological investigation. This study systematically reviews recent progress in MR research with frailty as the outcome measure, focusing on the application of this method in validating causal relationships between frailty and exposure factors such as lifestyle behaviors (smoking, alcohol consumption, sleep patterns, diet, physical activity), diseases (cardiometabolic diseases, inflammatory bowel disease, depression) and biomarkers (gut microbiota, blood lipids), enriching the understanding of pathogenic factors and prevention strategies for frailty, and providing a theoretical basis for subsequent clinical and public health decision-making.
文章引用：黄丽娟, 王敏娟. 孟德尔随机化在衰弱相关研究中的应用[J]. 临床医学进展, 2026, 16(2): 520-531. https://doi.org/10.12677/acm.2026.162421

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