膳食纤维对心血管肾代谢综合征患者的调控作用研究进展
Research Progress on the Regulatory Effect of Dietary Fiber on Patients with Cardiovascular-Kidney-Metabolic Syndrome
DOI: 10.12677/acm.2026.162441, PDF,    科研立项经费支持
作者: 徐 萌:山东大学第二临床学院,山东 济南;庄向华*:山东大学齐鲁第二医院内分泌代谢科,山东 济南
关键词: 膳食纤维心血管肾代谢综合征短链脂肪酸肠道微生物Dietary Fiber Cardiovascular-Kidney-Metabolic Syndrome Short-Chain Fatty Acids Gut Microbiota
摘要: 本文系统综述膳食纤维对心血管肾代谢综合征(CKM)患者的调控作用及其机制。结合近年研究进展,指出膳食纤维在降低CKM患者全因死亡率和心血管事件风险方面的积极潜力。膳食纤维主要利用其肠道发酵产物短链脂肪酸(SCFAs),发挥抑制全身性炎症、改善血管内皮功能、降低尿毒症毒素积累等作用,并在体重控制、糖脂代谢以及调节肠道微生物菌群的组成中发挥多重干预作用,从而对CKM患者的心、肾及代谢系统产生协同保护效果,为临床营养干预心血管肾代谢综合征提供理论依据。但膳食纤维在晚期肾病患者中的应用仍需谨慎并进一步研究。
Abstract: This article systematically reviews the regulatory effects and mechanisms of dietary fiber on patients with cardiovascular-kidney-metabolic syndrome (CKM). Based on recent research progress, it is pointed out that dietary fiber has a positive potential in reducing all-cause mortality and cardiovascular event risk in CKM patients. Dietary fiber mainly utilizes its intestinal fermentation products short-chain fatty acids (SCFAs) to inhibit systemic inflammation, improve vascular endothelial function, reduce the accumulation of uremic toxins, and play multiple intervention roles in weight control, glucose and lipid metabolism, and regulation of gut microbiota composition, thereby exerting a synergistic protective effect on the heart, kidney, and metabolic system of CKM patients, providing theoretical basis for clinical nutritional intervention in cardiovascular-kidney-metabolic syndrome. However, the use of dietary fiber in patients with advanced kidney disease still requires caution and further research.
文章引用:徐萌, 庄向华. 膳食纤维对心血管肾代谢综合征患者的调控作用研究进展[J]. 临床医学进展, 2026, 16(2): 699-706. https://doi.org/10.12677/acm.2026.162441

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