线粒体动力学相关生物标志物在脓毒症中的生物学机制研究进展
Research Progress on the Biological Mechanisms of Biomarkers Related to Mitochondrial Dynamics in Sepsis
DOI: 10.12677/acm.2026.162442, PDF,   
作者: 张杨宇博*, 曾 勇#：重庆医科大学附属第二医院急救部，重庆
关键词: 脓毒症；线粒体动力学；生物标志物；Sepsis； Mitochondrial Dynamics； Biomarkers
摘要: 本文综述了线粒体动力学(MD)及其相关基因(MD-RGs)作为脓毒症早期诊断生物标志物及治疗靶点的研究进展。脓毒症病死率高，早期诊断与干预至关重要，但目前缺乏有效的早期诊断标志物。线粒体动力学(融合与分裂)是维持细胞能量代谢和内稳态的核心，其在脓毒症中发生显著紊乱，导致线粒体碎片化、功能崩溃，进而加剧器官损伤与免疫炎症失调。文章重点指出，通过生物信息学分析筛选出的三个MD-RGs (RNF165、SLC22A4和UBE2C)在脓毒症患者中表达显著改变，并与免疫细胞浸润密切相关，显示出作为诊断生物标志物的潜力。实验验证进一步支持了这些基因的可靠性。此外，靶向线粒体动力学的干预策略(如抑制分裂蛋白DRP1)在临床前研究中展现出治疗前景。综上所述，该综述强调，深入研究线粒体动力学机制并挖掘相关生物标志物，对阐明脓毒症病理机制、实现早期诊断和开发靶向治疗新策略具有重要意义。未来需开展大规模临床验证，并探索其作为动态监测与预后评估工具的可行性。
Abstract: This article reviews the research progress regarding mitochondrial dynamics (MD) and its related genes (MD-RGs) as biomarkers for early diagnosis and therapeutic targets in sepsis. Sepsis carries a high mortality rate, making early diagnosis and intervention crucial; however, currently, there are no effective biomarkers for early detection. Mitochondrial dynamics, including fusion and fission, are essential for maintaining cellular energy metabolism and homeostasis. In sepsis, these processes are significantly disrupted, leading to mitochondrial fragmentation and functional collapse, which in turn exacerbates organ damage and immune-inflammatory disorders. The article highlights that three MD-RGs identified through bioinformatic analysis—RNF165, SLC22A4, and UBE2C—show significant changes in expression in patients with sepsis and are closely associated with immune cell infiltration, indicating their potential as diagnostic biomarkers. Experimental validation further supports the reliability of these genes. Additionally, intervention strategies targeting mitochondrial dynamics, such as inhibiting the fission protein DRP1, have shown promising therapeutic prospects in preclinical studies. In conclusion, this review emphasizes that in-depth research on mitochondrial dynamics and the identification of related biomarkers is of great significance for elucidating the pathogenic mechanisms of sepsis, enabling early diagnosis, and developing new targeted treatment strategies. In the future, large-scale clinical validation is needed, as well as exploration of their potential as tools for dynamic monitoring and prognostic assessment.
文章引用：张杨宇博, 曾勇. 线粒体动力学相关生物标志物在脓毒症中的生物学机制研究进展[J]. 临床医学进展, 2026, 16(2): 707-714. https://doi.org/10.12677/acm.2026.162442

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