代谢重编程与表观遗传调控在骨关节炎中的协同作用研究进展
Research Advances in the Synergistic Effects of Metabolic Reprogramming and Epigenetic Regulation in Osteoarthritis
DOI: 10.12677/acm.2026.162456, PDF,   
作者: 方少奇：绍兴文理学院医学院，浙江 绍兴；梁军波*：浙江省台州医院骨科，浙江 台州
关键词: 骨关节炎；软骨退变；代谢重编程；表观遗传；协同作用；Osteoarthritis (OA)； Cartilage Degeneration； Metabolic Reprogramming； Epigenetic； Synergistic Effect
摘要: 骨关节炎(OA)是一种以关节软骨退变为主要病理特征的常见退行性疾病，严重影响患者的生活质量。近年来，代谢重编程和表观遗传调控在OA软骨退变中的作用机制成为研究热点。软骨细胞在OA进展中经历显著的代谢异常，包括糖酵解增强、线粒体功能障碍及脂质代谢紊乱，这些变化与表观遗传修饰(如DNA甲基化、组蛋白乙酰化和非编码RNA调控)密切相关，共同促进软骨降解和炎症反应。本文系统综述了代谢重编程与表观遗传调控在OA软骨退变中的协同作用，阐明二者如何通过交互作用影响软骨细胞稳态，并探讨了靶向代谢–表观遗传通路的潜在治疗策略，为OA的精准干预提供新视角。
Abstract: Osteoarthritis (OA) is a common degenerative disease characterized primarily by cartilage degradation, which severely impairs patients’ quality of life. In recent years, the mechanisms of metabolic reprogramming and epigenetic regulation in OA cartilage degradation have become a research hotspot. Chondrocytes undergo significant metabolic abnormalities during OA progression, including enhanced glycolysis, mitochondrial dysfunction, and lipid metabolism disorders. These changes are closely associated with epigenetic modifications (such as DNA methylation, histone acetylation, and non-coding RNA regulation), which together promote cartilage degradation and inflammatory responses. This article systematically reviews the synergistic effects of metabolic reprogramming and epigenetic regulation in OA cartilage degradation, elucidates how they interact to affect chondrocyte homeostasis, and explores potential therapeutic strategies targeting metabolic-epigenetic pathways, providing new insights for the precise intervention of OA.
文章引用：方少奇, 梁军波. 代谢重编程与表观遗传调控在骨关节炎中的协同作用研究进展[J]. 临床医学进展, 2026, 16(2): 820-828. https://doi.org/10.12677/acm.2026.162456

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