夏枯草口服液和维生素D降低Graves病患者TRAb水平的作用探究

Study on the Effect of Prunella vulgaris Oral Liquid and Vitamin D in Reducing TRAb Levels in Patients with Graves’ Disease

摘要: 目的：探究甲巯咪唑(Methimazole, MMI)联合夏枯草口服液、维生素D治疗Graves病(Graves’ Disease, GD)，降低促甲状腺激素受体抗体(Thyrotropin Receptor Antibody, TRAb)水平的作用。方法：将于青岛大学附属医院内分泌门诊就诊的149名GD患者，分为MMI组(对照组，62例)、MMI + 夏枯草口服液组(44例)、MMI + 维生素D组(23例)、MMI + 夏枯草口服液 + 维生素D组(联合组，20例)，比较患者治疗6月后TRAb等甲状腺相关各指标水平的变化。结果：四组患者的年龄、性别、高血压情况、突眼情况无统计学差异(p > 0.05)，仅病程有统计学差异(p < 0.05)。与对照组相比，三个组的TRAb水平均有统计学差异(p < 0.05)，同时联合组与MMI + 维生素D组比较有统计学差异(p < 0.05)，但其余各项之间无统计学差异(p > 0.05)。结论：在四组方案中，联合组方案降低TRAb水平较对照组明显。

Abstract: Objective: To explore the effect of Methimazole (MMI) combined with Prunella vulgaris oral liquid and Vitamin D in the treatment of Graves’ disease (GD), and to reduce the level of Thyrotropin Receptor Antibody (TRAb). Methods: A total of 149 GD patients who visited the endocrinology outpatient department of the Affiliated Hospital of Qingdao University were divided into the MMI group (control group, 62 cases), the MMI + Prunella vulgaris oral liquid group (44 cases), the MMI + Vitamin D group (23 cases), and the MMI + Prunella vulgaris oral liquid + Vitamin D group (combined group, 20 cases). The changes in TRAb and other thyroid-related indicators after 6 months of treatment were compared among the groups. Results: There were no statistically significant differences in age, gender, hypertension, and exophthalmos among the four groups (p > 0.05), except for the disease duration (p < 0.05). Compared with the control group, the TRAb levels in all three groups showed statistically significant differences (p < 0.05). Meanwhile, the combined group had a statistically significant difference compared with the MMI + Vitamin D group (p < 0.05), but there were no statistically significant differences among the rest (p > 0.05). Conclusion: Among the four treatment regimens, the combined group showed a more significant reduction in TRAb levels compared to the control group.