手术治疗包绕三叉神经、面听神经的原发性中枢神经系统弥漫大B细胞淋巴瘤一例
Surgical Treatment of a Case of PCNS-DLBCL Encircling the Trigeminal and Facial-Acoustic Nerves
DOI: 10.12677/acm.2026.162469, PDF,    科研立项经费支持
作者: 杨菁滨, 庄志杰, 孔令舸, 冀文欢：宁夏医科大学第一临床医学院，宁夏 银川；宁夏医科大学总医院神经外科中心，宁夏 银川；刘嘉方：宁夏医科大学第二临床医学院，宁夏 银川；刘文庆, 郜彩斌, 刘仲涛*：宁夏医科大学总医院神经外科中心，宁夏 银川；曹相玫*：宁夏医科大学基础医学院，宁夏 银川
关键词: PCNS-DLBCL；三叉神经损伤；面听神经损伤；PCNS-DLBCL； Trigeminal Nerve Injury； Facial-Acoustic Nerve Injury
摘要: 原发性中枢神经系统弥漫性大B细胞淋巴瘤(Primary Central Nervous System Diffuse Large B-Cell Lymphoma, PCNS-DLBCL)指的是原发于脑、脊髓、颅神经、软脑膜和/或眼内的原发性弥漫性大B细胞淋巴瘤(Primary Diffuse Large B-Cell Lymphoma, Primary DLBCL)。它约占所有原发性中枢神经系统肿瘤的4%，占结外淋巴瘤的4%~6%。然而，包裹三叉神经或前庭蜗神经的弥漫性大B细胞淋巴瘤鲜有报道。本文报道1例51岁亚洲女性患者，因左侧三叉神经分布区麻木、疼痛及左侧面部抽搐3个月就诊。磁共振成像显示明确的鞍旁占位性病变，患者接受了枕下乙状窦后联合颞下入路肿瘤切除术。术中观察到肿瘤包裹三叉神经和前庭蜗神经，术后病理证实为弥漫性大B细胞淋巴瘤。
Abstract: Primary Central Nervous System Diffuse Large B-Cell Lymphoma (PCNS-DLBCL) refers to Primary Diffuse Large B-Cell Lymphoma (Primary DLBCL) occurring in the brain, spinal cord, cranial nerves, leptomeninges, and/or eyes. It accounts for approximately 4% of all primary central nervous system tumors and 4%~6% of extranodal lymphomas. However, DLBCL encasing the trigeminal or vestibulocochlear nerves is rarely reported. This article presents a case of a 51-year-old Asian female who presented with left trigeminal nerve distribution numbness, pain, and left facial twitching for three months. MRI revealed a definite parasellar occupying lesion. The patient underwent tumor resection via a combined suboccipital retrosigmoid and subtemporal approach. Intraoperatively, the tumor was observed encasing the trigeminal and vestibulocochlear nerves, and postoperative pathology confirmed diffuse large B-cell lymphoma.
文章引用：杨菁滨, 刘嘉方, 刘文庆, 郜彩斌, 庄志杰, 孔令舸, 冀文欢, 刘仲涛, 曹相玫. 手术治疗包绕三叉神经、面听神经的原发性中枢神经系统弥漫大B细胞淋巴瘤一例[J]. 临床医学进展, 2026, 16(2): 926-931. https://doi.org/10.12677/acm.2026.162469

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