溃疡性结肠炎小鼠模型的研究进展与模型选择考量
Research Advances and Model Selection Considerations in Mouse Models of Ulcerative Colitis
DOI: 10.12677/acm.2026.162434, PDF,   
作者: 姚 瑞：黑龙江中医药大学研究生院，黑龙江 哈尔滨；郑丽红*：黑龙江中医药大学附属第四医院消化内科，黑龙江 哈尔滨
关键词: 溃疡性结肠炎；动物模型；基因敲除；Ulcerative Colitis； Animal Model； Gene Knockout
摘要: 溃疡性结肠炎(UC)是一种病因尚未完全阐明的慢性炎症性肠病，其发病机制复杂，病程迁延难愈。动物模型作为研究UC发病机制及评价潜在治疗方法的核心工具，在基础与转化研究中具有不可替代的作用。文章系统梳理了目前广泛应用于UC研究的各类小鼠模型，详细阐述了不同模型的构建原理、方法要点、病理学特征及其在模拟人类UC临床表现与病理机制方面的优势与局限性，并重点探讨了各类模型在研究中的适用性与选择策略，以期为UC相关实验研究中的模型选择提供理论参考。
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease of incompletely elucidated etiology, characterized by complex pathogenesis and a protracted, refractory course. Animal models serve as indispensable tools for investigating UC pathogenesis and evaluating potential therapeutic interventions, playing an irreplaceable role in basic and translational research. This review systematically summarizes the various types of mouse models currently employed in UC research. It elaborates on the modeling principles, methodological details, pathological characteristics, and the respective advantages and limitations of these models in recapitulating human UC phenotypes. Furthermore, it discusses the applicability and selection strategies of these models in research contexts, aiming to provide a reference for selecting appropriate experimental models in UC-related studies.
文章引用：姚瑞, 郑丽红. 溃疡性结肠炎小鼠模型的研究进展与模型选择考量[J]. 临床医学进展, 2026, 16(2): 644-650. https://doi.org/10.12677/acm.2026.162434

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