肥胖型多囊卵巢综合征的中西医治疗研究进展

Research Progress on the Treatment of Obesity-Related Polycystic Ovary Syndrome with Traditional Chinese and Western Medicine

摘要: 多囊卵巢综合征(Polycystic Ovary Syndrome, PCOS)是一种常见的妇科内分泌疾病，在育龄期女性中发病率约为6%~13%。PCOS的临床表现复杂多样，如月经紊乱、不孕等生殖系统症状，以及肥胖、胰岛素抵抗等代谢异常表现。肥胖不仅加重PCOS的症状，远期还可增加糖尿病以及心血管疾病的发病风险。近年来，随着对PCOS与肥胖之间关系的深入研究，对PCOS肥胖的治疗方法也在不断优化，本文通过对相关研究的阅读及分析，探讨肥胖型PCOS的中西医治疗最新研究进展，旨在为临床实践提供更新的参考，以期改善肥胖型PCOS患者的生育及代谢健康状况。

Abstract: Polycystic Ovary Syndrome (PCOS) is one of the most prevalent endocrine disorders affecting women of reproductive age, with epidemiological studies indicating a global prevalence ranging from 6% to 13%, depending on diagnostic criteria and population characteristics. It is characterized by a triad of clinical features: chronic anovulation, hyperandrogenism, and polycystic ovarian morphology observed via ultrasound. Beyond these core manifestations, PCOS is frequently accompanied by a range of metabolic disturbances, among which obesity stands out as both a common comorbidity and a significant exacerbating factor. Approximately 40% to 80% of women diagnosed with PCOS are overweight or obese, particularly exhibiting central adiposity, which further intensifies insulin resistance, dyslipidemia, and systemic inflammation—key contributors to long-term complications such as type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. The interplay between obesity and PCOS creates a vicious cycle: excess body weight worsens hormonal imbalances and ovulatory dysfunction, while the underlying pathophysiology of PCOS, including hyperinsulinemia and altered adipokine secretion, promotes fat accumulation and makes weight loss more challenging. Given this bidirectional relationship, effective management of obesity has become a cornerstone in the treatment strategy for PCOS, aiming not only to improve fertility outcomes but also to mitigate metabolic risks. This article, through reading and analyzing relevant research, explores the latest research progress in the treatment of obese PCOS with both traditional Chinese and Western medicine, aiming to provide updated references for clinical practice and improve the reproductive and metabolic health of obese PCOS patients.