植物种子源活性肽的研究进展
Research Progress on Plant Seed-Derived Bioactive Peptides
DOI: 10.12677/hjfns.2026.153025, PDF,    科研立项经费支持
作者: 张悦然, 杨 帆, 陈壹刘, 周永鑫, 李咨诺, 徐 艺, 高 云*:辽宁科技大学化学工程学院,辽宁 鞍山
关键词: 植物种子生物活性肽制备方法生理活性Plant Seeds Bioactive Peptides Preparation Method Physiological Activity
摘要: 植物种子源活性肽(Plant seed-derived bioactive peptides, PSBPs)采用天然植物种子蛋白经过水解分离获得的小分子量蛋白质片段,因其独特的生理活性、安全性以及相对低廉的生产成本,是当前生物活性肽行业的研究热点。本文综合论述了PSBPs的分类及特点、制备方法、生理活性和应用领域,研究表明酶水解法是PSBPs最常用的制备方法,PSBPs的生理活性以抗氧化防衰老、免疫调节、降三高、抗炎防癌等为主,在食品、药品、化妆品及健康安全检测行业具有很好的应用前景。
Abstract: Plant seed derived bioactive peptides (PSBPs) are small molecular weight protein fragments obtained by hydrolysis and separation of natural plant seed proteins. Due to their unique physiological activity, safety, and relatively low production cost, they are currently a research hotspot in the bioactive peptide industry. This article comprehensively discusses the classification and characteristics, preparation methods, physiological activities, and application fields of PSBPs. Research has shown that enzymatic hydrolysis is the most commonly used preparation method for PSBPs. The physiological activities of PSBPs mainly include antioxidant and anti-aging, immune regulation, lowering three highs, anti-inflammatory and anti-cancer effects, and have good application prospects in the food, drug, cosmetics, and health and safety testing industries.
文章引用:张悦然, 杨帆, 陈壹刘, 周永鑫, 李咨诺, 徐艺, 高云. 植物种子源活性肽的研究进展[J]. 食品与营养科学, 2026, 15(3): 220-226. https://doi.org/10.12677/hjfns.2026.153025

参考文献

[1] Jia, L., Wang, L., Liu, C., Liang, Y. and Lin, Q. (2021) Bioactive Peptides from Foods: Production, Function, and Application. Food & Function, 12, 7108-7125. [Google Scholar] [CrossRef] [PubMed]
[2] Chai, K.F., Voo, A.Y.H. and Chen, W.N. (2020) Bioactive Peptides from Food Fermentation: A Comprehensive Review of Their Sources, Bioactivities, Applications, and Future Development. Comprehensive Reviews in Food Science and Food Safety, 19, 3825-3885. [Google Scholar] [CrossRef] [PubMed]
[3] 世界卫生组织: 各国元首承诺履行《全球非传染性疾病契约》, 到2030年挽救5000万人的生命[EB/OL].
https://www.who.int/zh/news/item/21-09-2022-heads-of-state-commit-to-noncommunicable-disease-global-compact-to-save-50-million-lives-by-2030, 2022-09-21.
[4] Liu, C., Wang, P., Yang, C., Zhao, B. and Sun, P. (2023) Comparative Assessment of Cucurbita moschata Seed Polypeptides toward the Protection of Human Skin Cells against Oxidative Stress-Induced Aging. Frontiers in Nutrition, 9, Article 1091499. [Google Scholar] [CrossRef] [PubMed]
[5] 郭溆, 田硕, 程安玮, 等. 酶解黄秋葵籽蛋白制备抗氧化肽的工艺优化[J]. 食品研究与开发, 2018, 39(24): 91-97.
[6] Guan, L., Zhu, L., Zhang, X., Han, Y., Wang, K., Ji, N., et al. (2024) Perilla Seed Oil and Protein: Composition, Health Benefits, and Potential Applications in Functional Foods. Molecules, 29, Article 5258. [Google Scholar] [CrossRef] [PubMed]
[7] Mudgil, P., Omar, L.S., Kamal, H., Kilari, B.P. and Maqsood, S. (2019) Multi-Functional Bioactive Properties of Intact and Enzymatically Hydrolysed Quinoa and Amaranth Proteins. LWT, 110, 207-213. [Google Scholar] [CrossRef
[8] Liao, A., Li, X., Gu, Z., He, J., Hou, Y., Pan, L., et al. (2022) Preparation and Identification of an Antioxidant Peptide from Wheat Embryo Albumin and Characterization of Its Maillard Reaction Products. Journal of Food Science, 87, 2549-2562. [Google Scholar] [CrossRef] [PubMed]
[9] Wu, H., Rui, X., Li, W., Xiao, Y., Zhou, J. and Dong, M. (2018) Whole-Grain Oats (Avena sativa L.) as a Carrier of Lactic Acid Bacteria and a Supplement Rich in Angiotensin I-Converting Enzyme Inhibitory Peptides through Solid-State Fermentation. Food & Function, 9, 2270-2281. [Google Scholar] [CrossRef] [PubMed]
[10] Fan, X., Ma, X., Maimaitiyiming, R., Aihaiti, A., Yang, J., Li, X., et al. (2023) Study on the Preparation Process of Quinoa Anti-Hypertensive Peptide and Its Stability. Frontiers in Nutrition, 9, Article 1119042. [Google Scholar] [CrossRef] [PubMed]
[11] Ma, X., Fan, X., Wang, D., Li, X., Wang, X., Yang, J., et al. (2022) Study on Preparation of Chickpea Peptide and Its Effect on Blood Glucose. Frontiers in Nutrition, 9, Article 988628. [Google Scholar] [CrossRef] [PubMed]
[12] Jiang, Y., Li, J., Zhao, H., Zhao, R., Xu, Y. and Lyu, X. (2020) Preparation of Grape Seed Polypeptide and Its Calcium Chelate with Determination of Calcium Bioaccessibility and Structural Characterisation. International Journal of Food Science & Technology, 56, 166-177. [Google Scholar] [CrossRef
[13] 陈思梦. 西瓜籽多肽提高肝肠热应激耐受性的途径及其分子机制[D]: [硕士学位论文]. 杭州: 江苏大学, 2023.
[14] Yang, J., Hong, J., Aihaiti, A., Mu, Y., Yin, X., Zhang, M., et al. (2024) Preparation of Sea Buckthorn (Hippophae rhamnoides L.) Seed Meal Peptide by Mixed Fermentation and Its Effect on Volatile Compounds and Hypoglycemia. Frontiers in Nutrition, 11, Article 1355116. [Google Scholar] [CrossRef] [PubMed]
[15] Yao, L., Huang, Q., Wang, H., Feng, T., Yu, C., Xie, K., et al. (2025) Unlocking Novel Biopeptides Hidden in Camellia Seed Cake Fermented by Bacillus subtilis through in Silico and Cellular Model Approaches. Food Chemistry, 476, Article ID: 143342. [Google Scholar] [CrossRef] [PubMed]
[16] Zhao, F., Wang, J., Lu, H., Fang, L., Qin, H., Liu, C., et al. (2020) Neuroprotection by Walnut-Derived Peptides through Autophagy Promotion via AKT/mTOR Signaling Pathway against Oxidative Stress in PC12 Cells. Journal of Agricultural and Food Chemistry, 68, 3638-3648. [Google Scholar] [CrossRef] [PubMed]
[17] Du, T., Huang, J., Xu, X., Xiong, S., Zhang, L., Xu, Y., et al. (2024) Effects of Fermentation with Lactiplantibacillus plantarum NCU116 on the Antihypertensive Activity and Protein Structure of Black Sesame Seed. International Journal of Biological Macromolecules, 262, Article ID: 129811. [Google Scholar] [CrossRef] [PubMed]
[18] Zhao, Y., Zhang, T., Ning, Y., Wang, D., Li, F., Fan, Y., et al. (2023) Identification and Molecular Mechanism of Novel Tyrosinase Inhibitory Peptides from the Hydrolysate of ‘Fengdan’ Peony (Paeonia ostii) Seed Meal Proteins: Peptidomics and in Silico Analysis. LWT, 180, Article ID: 114695. [Google Scholar] [CrossRef
[19] 陶瑾, 张莉方, 徐宁莉, 等. 青稞蛋白降血糖肽的纯化、结构鉴定及体外降血糖和抗氧化活性[J]. 中国粮油学报, 2023, 38(11): 92-99.
[20] Semwal, J. and Meera, M.S. (2025) Thermally-Induced Modulations of Starch and Protein Characteristics in Sorghum Grain. Journal of Food Measurement and Characterization, 19, 2220-2232. [Google Scholar] [CrossRef
[21] Boschin, G., Scigliuolo, G.M., Resta, D. and Arnoldi, A. (2014) Ace-inhibitory Activity of Enzymatic Protein Hydrolysates from Lupin and Other Legumes. Food Chemistry, 145, 34-40. [Google Scholar] [CrossRef] [PubMed]
[22] Lin, F., Chen, L., Liang, R., Zhang, Z., Wang, J., Cai, M., et al. (2011) Pilot-Scale Production of Low Molecular Weight Peptides from Corn Wet Milling Byproducts and the Antihypertensive Effects in Vivo and in Vitro. Food Chemistry, 124, 801-807. [Google Scholar] [CrossRef
[23] Valdez-Miramontes, C.E., De Haro-Acosta, J., Aréchiga-Flores, C.F., Verdiguel-Fernández, L. and Rivas-Santiago, B. (2021) Antimicrobial Peptides in Domestic Animals and Their Applications in Veterinary Medicine. Peptides, 142, Article ID: 170576. [Google Scholar] [CrossRef] [PubMed]
[24] Hu, Y., Ling, Y., Qin, Z., Huang, J., Jian, L. and Ren, D.F. (2024) Isolation, Identification, and Synergistic Mechanism of a Novel Antimicrobial Peptide and Phenolic Compound from Fermented Walnut Meal and Their Application in Rosa Roxbughii Tratt Spoilage Fungus. Food Chemistry, 433, Article ID: 137333. [Google Scholar] [CrossRef] [PubMed]
[25] Kong, X., Song, W., Hua, Y., Li, X., Chen, Y., Zhang, C., et al. (2020) Insights into the Antibacterial Activity of Cottonseed Protein-Derived Peptide Against Escherichia coli. Food & Function, 11, 10047-10057. [Google Scholar] [CrossRef] [PubMed]
[26] Ye, X., Ng, T., Wu, Z., Xie, L., Fang, E.F., Wong, J., et al. (2011) Protein from Red Cabbage (Brassica oleracea) Seeds with Antifungal, Antibacterial, and Anticancer Activities. Journal of Agricultural and Food Chemistry, 59, 10232-10238. [Google Scholar] [CrossRef] [PubMed]
[27] Ndiaye, F., Vuong, T., Duarte, J., Aluko, R.E. and Matar, C. (2012) Anti-Oxidant, Anti-Inflammatory and Immunomodulating Properties of an Enzymatic Protein Hydrolysate from Yellow Field Pea Seeds. European Journal of Nutrition, 51, 29-37. [Google Scholar] [CrossRef] [PubMed]
[28] 丁淑婷. 多肽受体PSKR1和钙依赖蛋白CPK28互作调控番茄生长和抗病性的分子机制[D]: [博士学位论文]. 杭州: 浙江大学, 2022.
[29] 刘婉月, 吕沛宣, 杨雅梦, 等. 植物多肽的制备及在食品中应用的研究进展[J]. 食品工业科技, 2021, 42(24): 407-416.
[30] 崔本文, 林梦君, 王辉辉, 等. 化妆品多肽结构改造的有效策略[J]. 日用化学品科学, 2023, 46(2): 54-57.
[31] 李思楠, 王玺, 安宇, 等. 植物源生物活性肽的制备、生理活性及作用机制研究进展[J]. 食品工业科技, 2025, 46(3): 394-402.