纳米晶药物制备技术的发展
Development of Nanocrystalline Drug Preparation Technology
摘要: 纳米晶药物可显著提升难溶性药物的溶解度与溶出速率，兼具高载药量、低辅料风险、给药途径灵活、可靶向修饰等优势，是破解上述难题的核心制剂方案。目前纳米晶主流制备技术分为“自下而上”“自上而下”及组合技术三类，各类技术各有优势与工业化应用瓶颈。综上，纳米晶技术在难溶性药物成药性改良领域优势突出，虽仍面临稳定性、工艺放大等挑战，但在创新药与改良型新药研发中具备广阔的应用前景。
Abstract: Nanocrystalline drugs can significantly improve the solubility and dissolution rate of poorly soluble drugs. They possess the advantages of high drug loading, low excipient-related risks, flexible administration routes, and targetable modification, serving as a core formulation strategy to address the above challenges. At present, the mainstream preparation technologies of nanocrystals are classified into three categories: “bottom-up”, “top-down” and combined technologies. Each technology has its own advantages and bottlenecks in industrial application. In conclusion, nanocrystal technology shows prominent superiority in improving the druggability of poorly soluble drugs. Although challenges such as stability and process scale-up still exist, it has broad application prospects in the research and development of innovative drugs and modified new drugs.
文章引用：高福振, 朱红玉. 纳米晶药物制备技术的发展[J]. 药物化学, 2026, 14(2): 119-126. https://doi.org/10.12677/hjmce.2026.142012

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