复合益生菌较单一菌粉对斑马鱼肠道动力的调节研究
Study on the Regulation of Zebrafish Intestinal Motility by Probiotic Mixtures Compared to Single Strain Powders
DOI: 10.12677/hjfns.2026.154052, PDF,   
作者: 方晓晖, 张浩天：镇江远森医药科技有限公司研发部，江苏 镇江；金东宁：合肥综合性国家科学中心大健康研究院慢性疾病药物中心，安徽 合肥；沈 刚, 徐 玮：江苏远森健康产业有限公司研发部，江苏 镇江
关键词: 复合益生菌粉；斑马鱼；润肠通便；代谢物；Compound Probiotic Powder； Zebrafish； Promote Bowel Movement； Metabolites
摘要: 本研究聚焦于益生菌的润肠通便功效，利用非靶向代谢组学分析复合益生菌粉(鼠李糖乳酪杆菌LGc、罗伊氏粘液乳杆菌DSM0798、瑞士乳杆菌Ys-299、植物乳植杆菌LD-295、短双歧杆菌YSs12、动物双歧杆菌动物亚种BB-14X)与单一益生菌粉(鼠李糖乳酪杆菌LGc/罗伊氏粘液乳杆菌DSM0798/瑞士乳杆菌Ys-299/植物乳植杆菌LD-295/短双歧杆菌YSs12/动物双歧杆菌动物亚种BB-14X)的代谢物差异，通过斑马鱼模型进一步分析其功效及潜在机制，实验表明，复合益生菌粉能够有效促进肠道蠕动，并增加5-羟色胺的生物合成，同时能够在肠道中有效定植24 h以上。
Abstract: This study focuses on the laxative effect of probiotics. Non-targeted metabolomics was applied to analyze the metabolite differences between compound probiotic powder (Lacticaseibacillus rhamnosus LGc, Limosilactobacillus reuteri DSM0798, Lactobacillus helveticus Ys-299, Lactiplantibacillus plantarum LD-295, Bifidobacterium breve YSs12, and Bifidobacterium animalis subsp. lactis BB-14X) and single-strain probiotic powder (each of the aforementioned strains individually). A zebrafish model was used to further investigate the efficacy and potential underlying mechanism. Experimental results indicate that the compound probiotic powder can effectively promote intestinal peristalsis, enhance the biosynthesis of 5-hydroxytryptamine, and achieve stable colonization in the intestinal tract for more than 24 hours.
文章引用：方晓晖, 张浩天, 金东宁, 沈刚, 徐玮. 复合益生菌较单一菌粉对斑马鱼肠道动力的调节研究[J]. 食品与营养科学, 2026, 15(4): 484-491. https://doi.org/10.12677/hjfns.2026.154052

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