一氧化氮和天然抗氧化剂对血管稳定性的调节和保护作用

Protective Effect of Nitric Oxide and Natural Antioxidants on Stability of Blood Vessel

摘要: 本文研究了一个一氧化氮和天然抗氧化剂合理搭配组合对kkay小鼠血脂和血糖及大鼠血压的调节和保护作用。结果发现，喂食高脂饲料导致易肥胖kkay小鼠体重增加、肝脏增生、血脂四项显著增加和血糖的大幅度升高，而灌胃一氧化氮和天然抗氧化剂搭配组合后可以显著减少由高脂饲料引起的kkay小鼠体重的增加(低剂量和高剂量分别减少大约9%和12.5%)，明显降低高脂引起的肝脏系数增加(低剂量和高剂量分别降低17.8%和20.2%)，明显降低总胆固醇的含量(低剂量和高剂量分别降低11.0%和15.6%)，显著降低甘油三脂的含量(低剂量和高剂量分别减少29.8%和35.5%)，显著降低低密度脂蛋白(低剂量和高剂量分别减少24.6%和25.4%)，但却升高高密度脂蛋白(低剂量和高剂量分别升高4.8%和18.9%)。灌胃一氧化氮和天然抗氧化剂搭配组合后，可以显著降低kkay小鼠的空腹血糖(低剂量和高剂量分别降低36.2%和44.1%)、随机血糖(低剂量和高剂量分别降低47.6%和56.7%)、和餐后2小时血糖(低剂量和高剂量分别降低33.1%和44.1%)；喂养高脂饲料诱导了大鼠的收缩压大幅度升高大约73%，灌胃搭配组合后一个月，低剂量和高剂量可以分别显著降低大鼠的血压大约12%和18%。进一步研究发现，这个组合对羟基和超氧阴离子自由基有明显清除作用，说明一氧化氮和天然抗氧化剂合理搭配组合可能是通过清除氧自由基防止高脂饮食和基因引起的血管损伤，对血管起调节和保护作用。

Abstract: The protective effects of a formula of nitric oxide and natural antioxidants on increases of blood lipid, and glucose of kkay mouse and blood pressure of rat caused by higher lipid food were studied. It was found that higher lipid food and gene caused significant increase body weight, liver weight and blood lipid and blood glucose of kkay mouse, while the formula of nitric oxide and natural antioxidants could decrease the increases of body weight (about 9% and 12.5% for low and high doses respectively), liver weight/body weight (about 17.8% and 20.2% for low and high doses respectively), cholesterol (about 11.0% and 15.6% for low and high doses respectively), triglyceride (about 29.8% and 35.5% for low and high doses respectively), low density lipid protein (about 24.6% and 25.4% for low and high doses respectively), however increase the high density lipid protein (about4.8% and 18.9% for low and high doses respectively). The formula also could decrease the increases of fasting blood glucose (about 36.2% and 44.1% for low and high doses respectively), random blood glucose (about 47.6% and 56.7% for low and high doses respectively) and 2-hour blood glucose (about 33.1% and 44.1% for low and high doses respectively). It was also found that higher lipid food caused significant increase of blood pressure of rats about 73% and that the formula could decrease the blood pressure about 12% and 18% for low and high doses respectively. Further study found that the formula could scavenge hydroxyl and superoxide free radicals. It suggests that the formula of nitric oxide and natural antioxidants can protect blood vessel against the damage caused by higher lipid food and genetic factors through scavenging oxygen free radicals.