中药复方片的降血脂药效学研究

The Hypolipidemic Effect of a Traditional Chinese Medicine Compound Tablet

摘要: 目的：考察由天麻、制何首乌、川芎、丹参、葛根组成的新中药复方片剂的降血脂作用，为临床应用提供参考依据。方法：SD大鼠，随机分为7个组，普通饲料组、高脂饲料模型组、该中药复方片剂低剂量组、该中药复方片剂中剂量组、该中药复方片剂高剂量组、天麻首乌片组，辛伐他汀片组，除普通饲料组外，其余各组采用高脂饲料喂养大鼠，连续14天，造成高脂血症模型，并于15天开始各组灌胃给予该中药复方片剂(0.95 g生药/kg，1.90 g生药/kg，3.80 g生药/kg)、天麻首乌片(1.28 g生药/kg)及辛伐他汀(28.8 mg/kg)，给药体积为10ml/kg，每天1次，连续14天，于末次给药60 min后，测定各组大鼠血清甘油三酯(TG)，总胆固醇(TC)，高密度脂蛋白胆固醇(HDL-C-C)，低密度脂蛋白胆固醇(LDL-C)。结果：该中药复方片剂组、天麻首乌片组、辛伐他汀组对大鼠体重无明显影响(P > 0.05)，该中药复方片剂(1.90 g生药/kg，3.80 g生药/kg)能降低高脂模型动物总胆固醇、甘油三酯、低密度脂蛋白(P < 0.05)，能升高高脂模型大鼠高密度脂蛋白(P < 0.05)。结论：该中药复方片剂具有降低高脂饲料致高血脂症模型大鼠血脂的作用。

Abstract: Objective: To observe the effect of Chinese herbal compound tablet on hypolipidemic effect, and to provide reference for clinical application. Methods: SD rats were randomly divided into 7 groups: normal diet group, high fat diet model group, low dose group of traditional Chinese medicine compound tablet, middle dose group of traditional Chinese medicine compound tablet, high dose group of traditional Chinese medicine compound tablet, Tianma Shouwu Group, simvastatin group. In addition to the general diet group, the other groups were fed with high-fat diet rats for 14 days, resulting in hyperlipidemia model, and in 15 days after each group were given the traditional Chinese medicine compound tablets (0.95 g/kg, 1.90 g/kg, 3.80 g/kg), Tianma Shouwu Tablets (1.28 g/kg) and simvastatin (28.8 mg/kg). Administration volume of 10 ml/kg, once a day for 14 days, after the last administration of 60 min, Serum triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were measured. Results: The traditional Chinese medicine compound tablet group, Tianma Shouwu tablet group and Simvastatin group had no significant effect on the body weight of rats (P > 0.05). The traditional Chinese medicine compound tablet (1.90 g crude drug / kg, 3.80 g crude drug/kg) can reduce high fat model animal total cho-lesterol (TC), triglyceride, low density lipoprotein (LDL-C) (P < 0.05), and increase high fat rat model Density lipoprotein (P < 0.05). Conclusion: The traditional Chinese medicine compound tablet has the effect of reducing the blood lipid of hyperlipidemia induced hyperlipidemia rats.