辅料对青皮配方颗粒喷雾干燥抗粘壁作用效果的研究

Research on Effects of Excipients on Wall Sticking Prevention in Spray Drying of Qing Pi Formula Granules

摘要: 目的：研究不同辅料对青皮喷雾干燥抗粘壁的作用效果。方法：采用L9(34)正交设计法，以收粉率、含水量为指标，考察倍他环糊精、CMC-Na、进风温度对青皮喷雾干燥的影响，优化喷雾干燥工艺关键参数，优选最佳辅料配比和工艺参数。结果：CMC-Na添加量对收粉率有显著影响P < 0.05，进风温度对干粉含水量有显著影响P < 0.05。结论：优选喷雾干燥工艺为：倍他环糊精8%，CMC-Na 2%，糊精6%，进风温度185℃。

Abstract: Objective: Research on effects of different excipients on wall sticking prevention during spray drying process of Qi Pi formula granules. Method: With powder-collecting rate and water con-tent as indicators, the impacts of β-cyclodextrin, CMC-Na and inlet air temperature on spray drying of Qi Pi formula granules are observed by adopting the L9(34) orthogonal design method, so as to optimize key parameters of spray drying process and obtain the optimal excipients ratio and process parameters. Results: Dosage of CMC-Na has significant effect on powder-collecting rate (P < 0.05), inlet air temperature has significant effect on water content of dry powder (P < 0.05). Conclusions: The optimal spray drying process includes 8% β-cyclodextrin, 2% CMC-Na, 6% dextrin and inlet air temperature 185˚C.