无机纳米材料在成像诊断方面的应用
Application of Inorganic Nanomaterials in Imaging Diagnosis
DOI: 10.12677/JAPC.2018.72005, PDF,    国家自然科学基金支持
作者: 冯华阳, 李景果*：郑州大学材料科学与工程学院，河南 郑州;郑州大学人民医院，河南 郑州；任苗柠, 范冰冰：郑州大学材料科学与工程学院，河南 郑州
关键词: 磁性氧化铁；介孔氧化硅；金纳米颗粒；上转换纳米材料；半导体量子点；成像诊断；双模态成像；Magnetic Iron Oxide； Mesoporous Silica； Gold Nanoparticles； Up-Conversion Nanomaterials； Semiconductor Quantum Dots； Imaging Diagnosis； Dual Mode Imaging
摘要: 无机纳米材料是大多数造影剂的主要部分，起到增强病患部位与周围组织对比度的作用，引起了生物、化学、物理和材料等各领域科学家的广泛关注。其种类包括用于磁共振成像(MRI)的磁性氧化铁材料，用于CT成像和光热治疗的纳米金材料，可与无机造影材料复合的介孔二氧化硅材料，用作无背影荧光成像的上转换发光材料和半导体量子点荧光材料。本文主要综述了以上材料的物理化学特性、合成方法及其在成像诊断方面的应用，并对该领域的研究进行了相应的展望。
Abstract: Inorganic nanomaterials, a major part of most contrast media, have received wide attention due to their strong ability to enhance the contrast between the affected area and the surrounding tissue. In recent years, some inorganic nanomaterials such as magnetic iron oxide materials, nano gold materials, mesoporous silica materials and so on have been widely applied to magnetic resonance imaging, CT imaging, fluorescence imaging and so on. This article reviews the physicochemical properties of the above materials, the synthesis methods and their application in the field of imaging diagnosis, and gives a corresponding outlook for the research in this field.
文章引用：冯华阳, 任苗柠, 范冰冰, 李景果. 无机纳米材料在成像诊断方面的应用[J]. 物理化学进展, 2018, 7(2): 37-47. https://doi.org/10.12677/JAPC.2018.72005

参考文献

[1] Park, S., Aalipour, A., Vermesh, O., et al. (2017) Towards Clinically Translatable In Vivo Nanodiagnostics. Nature Reviews Materials, 2, 17014. [Google Scholar] [CrossRef] [PubMed]
[2] Hyeon, T., Lee, S.S., Lee, S.S., et al. (2001) Synthesis of Highly Crystalline and Monodisperse Maghemite Nanocrystallites without a Size-Selection Process. Cheminform, 123, 12798. [Google Scholar] [CrossRef] [PubMed]
[3] Song, H.-T., et al. (2005) Surface Modulation of Magnetic Nanocrystals in the Development of Highly Efficient Magnetic Resonance Probes for Intracellular Labeling. Journal of the American Chemical Society, 127, 9992-9993. [Google Scholar] [CrossRef] [PubMed]
[4] Ling, D., Lee, N. and Hyeon, T. (2015) Chemical Synthesis and Assembly of Uniformly Sized Iron Oxide Nanoparticles for Medical Applications. Accounts of Chemical Research, 48, 1276-1285. [Google Scholar] [CrossRef] [PubMed]
[5] Kim, B.H., Lee, N., Kim, H., et al. (2011) Large-Scale Synthesis of Uniform and Extremely Small-Sized Iron Oxide Nanoparticles for High-Resolution T1 Magnetic Resonance Imaging Contrast Agents. Journal of the American Chemical Society, 133, 12624-12631. [Google Scholar] [CrossRef] [PubMed]
[6] Li, Z., Wei, L., Gao, M.Y., et al. (2010) One-Pot Reaction to Synthesize Biocompatible Magnetite Nanoparticles. Advanced Materials, 17, 1001-1005. [Google Scholar] [CrossRef] 
[7] Liong, M., Angelos, S., Choi, E., et al. (2009) Mesostructured Multifunctional Nanoparticles for Imaging and Drug Delivery. Journal of Materials Chemistry, 19, 6251-6257. [Google Scholar] [CrossRef] 
[8] Chen, Y., Chen, H., Sun, Y., et al. (2011) Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High-Intensity Focused Ultrasound Cancer Surgery. Angewandte Chemie, 50, 12505-12509. [Google Scholar] [CrossRef] [PubMed]
[9] Lee, C.-H., Cheng, S.-H., Wang, Y.-J., et al. (2009) Near-Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution. Advanced Functional Materials, 19, 215-222. [Google Scholar] [CrossRef] 
[10] 施剑林, 陈雨, 陈航榕. 多功能介孔氧化硅基纳米诊疗剂的研究进展[J]. 无机材料学报, 2013, 28(1): 1-11.
[11] Phillips, E., Penatemedina, O., Zanzonico, P.B., et al. (2014) Clinical Translation of an Ultrasmall Inorganic Optical-PET Imaging Nanoparticle Probe. Science Translational Medicine, 6, 260ra149. [Google Scholar] [CrossRef] [PubMed]
[12] Daniel, M.C. and Astruc, D. (2004) Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology. Chemical Reviews, 104, 293. [Google Scholar] [CrossRef] [PubMed]
[13] Sepúlveda, B., Angelomé, P.C., Lechuga, L.M., et al. (2009) LSPR-Based Nanobiosensors. Nanotoday, 4, 244-251. [Google Scholar] [CrossRef] 
[14] Okuno, M. and Hamaguchi, H. (2010) Multifocus Confocal Raman Microspectroscopy for Fast Multimode Vibrational Imaging of Living Cells. Optics Letters, 35, 4096-4098. [Google Scholar] [CrossRef] 
[15] Hainfeld, J.F., Slatkin, D.N. and Smilowitz, H.M. (2004) The Use of Gold Nanoparticles to Enhance Radiotherapy in Mice. Physics in Medicine & Biology, 49, 309-315. [Google Scholar] [CrossRef] 
[16] Wang, H., Zheng, L., Guo, R., et al. (2012) Den-drimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Blood Pool Imaging. Nanoscale Research Letters, 7, 1-8. [Google Scholar] [CrossRef] 
[17] Bardhan, R., Lal, S., Joshi, A., et al. (2011) Theranostic Nanoshells: From Probe Design to Imaging and Treatment of Cancer. Accounts of Chemical Research, 44, 936-946. [Google Scholar] [CrossRef] [PubMed]
[18] Yang, X., Stein, E., Wei, X., et al. (2008) Photoacoustic Tomography with Novel Optical Contrast Agents Based on Gold Nanocages or Nanoparticles Containing Near-Infrared Dyes. Proceedings of SPIE—The International Society for Optical Engineering, 6856, 1-10. [Google Scholar] [CrossRef] 
[19] Chen, G., Qiu, H., Prasad, P.N. and Chen, X. (2014) Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics. Chemical Reviews, 114, 5161-5214. [Google Scholar] [CrossRef] [PubMed]
[20] Haase, M. and Schfer, H. (2011) Upconverting Nanoparticles. An-gewandte Chemie International Edition, 50, 5808-5829. [Google Scholar] [CrossRef] [PubMed]
[21] Gu, Z., et al. (2013) Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications. Advanced Materials, 25, 3758-3779. [Google Scholar] [CrossRef] [PubMed]
[22] Wang, F., Banerjee, D., Liu, Y., et al. (2010) Upconversion Nanoparticles in Biological Labeling, Imaging, and Therapy. Analyst, 135, 1839-1854.
[23] Chatterjee, D.K., Rufaihah, A.J. and Zhang, Y. (2008) Upconversion Fluorescence Imaging of Cells and Small Animals Using Lanthanide Doped Nanocrystals. Biomaterials, 29, 937. [Google Scholar] [CrossRef] [PubMed]
[24] Yu, X., Li, M., Xie, M., et al. (2010) Dopant-Controlled Synthesis of Water-Soluble Hexagonal NaYF4, Nanorods with Efficient Upconversion Fluorescence for Multicolor Bioimaging. Nano Research, 3, 51-60. [Google Scholar] [CrossRef] 
[25] Wang, F. and Liu, X. (2008) Upconversion Multicolor Fi-ne-Tuning: Visible to Near-Infrared Emission from Lanthanide-Doped NaYF4 Nanoparticles. Journal of the American Chemical Society, 130, 5642-5643. [Google Scholar] [CrossRef] [PubMed]
[26] Park, Y.I., et al. (2009) Nonblinking and Nonbleaching Upconverting Nanoparticles as an Optical Imaging Nanoprobe and T1 Magnetic Resonance Imaging Contrast Agent. Advanced Materials, 21, 4467-4471. [Google Scholar] [CrossRef] 
[27] 余启钰, 刘春艳. 用于生物标记的半导体量子点研究[J]. 影像科学与光化学, 2006, 24(5): 382-390.
[28] Hines, M.A. and Guyot-Sionnest, P. (1998) Bright UV-Blue Luminescent Colloidal ZnSe Nanocrystals. The Journal of Physical Chemistry B, 102, 3655-3657.
[29] Prieto, J.A., Armelles, G., Groenen, J., et al. (1999) Size and Strain Effects in the E1-Like Optical Transitions of InAs/InP Self-Assembled Quantum Dot Structures. Applied Physics Letters, 74, 99-101. [Google Scholar] [CrossRef] 
[30] Bruchez Jr, M., Moronne, M., Gin, P., Weiss, S. and Alivisatos, A.P. (1998) Semiconductor Nanocrystals as Fluorescent Biological Labels. Science, 281, 2013-2015. [Google Scholar] [CrossRef] [PubMed]
[31] Han, M., Gao, X., Su, J.Z. and Nie, S. (2001) Quan-tum-Dot-Tagged Microbeads for Multiplexed Optical Coding of Biomolecules. Nature Biotechnology, 19, 631-635. [Google Scholar] [CrossRef] [PubMed]
[32] Gaponik, N., et al. (2002) Efficient Phase Transfer of Luminescent Thi-ol-Capped Nanocrystals: From Water to Nonpolar Organic Solvents. Nano Letters, 2, 803-806. [Google Scholar] [CrossRef] 
[33] Murray, C.B., Norris, D.J. and Bawendi, M.G. (1993) Synthesis and Characterization of Nearly Monodisperse Semiconductor Nanocrystallites. Journal of the American Chemical Society, 115, 8706-8715. [Google Scholar] [CrossRef] 
[34] Robert, E.B., Andrew, M.S. and Nie, S.M. (2004) Quantum Dots in Biology and Medicine. Journal of Physics E, 25, 1-12.
[35] Gao, X., Cui, Y., Levenson, R.M., et al. (2004) In Vivo Cancer Targeting and Imaging with Semiconductor Quantum Dot. Nature Biotechnology, 22, 969-976. [Google Scholar] [CrossRef] [PubMed]
[36] Louie, A. (2010) Multimodality Imaging Probes: Design and Challenges. Chemical Reviews, 110, 3146-3195. [Google Scholar] [CrossRef] [PubMed]
[37] Kim, D., Yu, M.K., Lee, T.S., et al. (2011) Amphiphilic Polymer-Coated Hybrid Nanoparticles as CT/MRI Dual Contrast Agents. Nanotechnology, 22, 155101. [Google Scholar] [CrossRef] [PubMed]
[38] Zhu, J., Lu, Y., Li, Y., et al. (2014) Synthesis of Au-Fe3O4 Heterostructured Nanoparticles for In Vivo Computed Tomography and Magnetic Resonance Dual Model Imaging. Nanoscale, 6, 199. [Google Scholar] [CrossRef] 
[39] Wu, C., Li, J., Pang, P., et al. (2014) Polymeric Vector-Mediated Gene Transfection of MSCs for Dual Bioluminescent and MRI Tracking In Vivo. Biomaterials, 35, 8249-8260. [Google Scholar] [CrossRef] [PubMed]
[40] Suchý, M., Bartha, R. and Hudson, R.H.E. (2013) “Click” Chemistry toward Bis(DOTA-Derived) Heterometallic Complexes: Potential Bimodal MRI/PET(SPECT) Molecular Imaging Probes. RSC Advances, 3, 3249-3259. [Google Scholar] [CrossRef] 
[41] Zhu, J., Zhang, B., Tian, J., et al. (2015) Synthesis of Heterodimer Radionuclide Nanoparticles for Magnetic Resonance and Single-Photon Emission Computed Tomography Dual-Modality Imaging. Nanoscale, 7, 3392-3395. [Google Scholar] [CrossRef]