糖球造孔法制备三维多孔钛支架及性能表征

Construction and Characterization of Porous Ti Scaffolds by Sugar Spheres Agent

摘要: 骨组织工程支架的贯通性及其力学性能对其体内的生物学表现具有重要影响。多孔支架结构在骨组织修复和替换过程中起着支撑细胞黏附的作用。本研究以钛粉为原料，采用甲壳素溶胶体系和糖球造孔剂制备多孔Ti支架，考察不同Ti含量浓度对支架的孔隙率、收缩率、宏孔尺寸及抗压强度的影响。结果表明，当Ti浓度为50%时，支架具有相对优异的孔隙结构及抗压强度，Ti含量为30%，支架易在烧结过程中发生塌陷，而Ti浓度为70%时，会使得支架孔隙较为封闭，贯通性变差。后续对Ti-50支架应用两种方法进行干燥，考察自然干燥法与冷冻干燥法下支架的收缩率与质量降低率。结果表明，冷冻干燥法对支架进行干燥后，更利于样品形貌的保持。

Abstract: Interconnectivity and mechanical properties of bone tissue engineering scaffolds plays a very im-portant role in biological performance in vivo. Porous scaffolds play the role in supporting cell adhesion in the process of bone tissue repair or replacement. In this study, the titanium powder was used for preparing highly interconnected porous scaffolds by sugar spheres agent and gel-casting methods. The effects of Ti concentration on porosity, shrinkage, macropore size and compressive strength of the scaffolds were investigated. The results show that the Ti-50 scaffold has relatively excellent pore structure and compressive strength. However, Ti-30 scaffold is prone to collapse in the sintering process, and Ti-70 scaffold will make the pore of the scaffold more closed. The effects of different drying methods on the shrinkage rate and mass reduction rate of the Ti-50 scaffold were also investigated. The results showed that after freeze-drying, the Ti-50 scaffolds were more favorable to maintain the morphology than after natural drying method.