磁过滤阴极真空弧源法制备纳米晶铁膜的生物相容性研究

Biocompatibility of Nanocrystal Iron Film Prepared by Filtered Cathodic Vacuum Arc

摘要: 铁及其合金是非常有潜力的血管支架材料，但就如何制备出具有良好细胞相容性和血液相容性的表面而言仍然充满挑战。本文通过磁过滤阴极真空弧源法在硅片表面沉积了纳米晶铁膜，用X射线衍射分析了纳米晶铁膜的物相结构，采用人脐静脉内皮细胞评价了薄膜的细胞相容性，血小板粘附实验评价了纳米晶铁膜的血液相容性。结果表明纳米晶铁膜表面提高了人脐静脉内皮细胞的粘附和增殖，同时，作为一种血液接触材料，纳米晶铁膜有抑制血小板粘附和激活的趋势。这些数据都表明纳米晶铁膜在改善血管植入器械的生物相容性上有巨大潜力。

Abstract: Iron and its alloys appear a high potential as biodegradable vascular stents materials, however, establishing a surface with good cytocompatibility and hemocompatibility remains a challenge. In this work, nanocrystal iron (NC-Fe) film was deposited on silicon substrate by filtered cathodic vacuum arc technique, the phase structure of NC-Fe film was analyzed by X-ray diffraction, we also cultured human umbilical vein endothelial cells (HUVECs) and human platelet on the film to in-vestigate the cellular and blood compatibilities of the film. We found that the NC-Fe film surface significantly enhanced HUVEC adhesion and proliferation. Meanwhile, the NC-Fe film tended to in-hibit platelet adhesion and activation. These data suggest the good potential of the NC-Fe film for improving biocompatibility of vascular devices.