细菌纤维素荷载利福平的方法及药效初步评价

Preliminary Evaluation of Bacterial Cellulose-Loaded Rifampicin and Its Efficacy

摘要: 皮肤结核和麻风是以皮肤病变为主的传染病，烧伤、烫伤和机械破损是造成皮肤功能障碍的常见外科病，目前缺乏有效的皮肤修复制剂。本试验以细菌纤维素为材料，采用煮沸法荷载利福平，得到利福平纤维素膜。结果表明，利福平主要荷载于细菌纤维素的基质中，每cm2载药纤维素膜的质量为6 mg，载药量为5100 μg/cm2。动物试验显示，药片以自然融合的方式填补皮肤破损，发挥天然皮肤的作用。本试验为进一步研发广谱皮肤修复制剂奠定了基础。

Abstract: Skin tuberculosis and leprosy are infectious diseases with skin lesions. Burns, hot scald and me-chanical damage are common surgical diseases that cause skin dysfunction. However, there are no effective skin-repairing preparations currently. In this study, rifampicin-cellulose film was pre-pared by boiling method based on bacterial cellulose. The results showed that rifampicin was mainly loaded in the matrix of bacterial cellulose. The weight of the drug-loaded cellulose mem-brane was 6 mg per cm2. The drug loading was 5100 μg/cm2. Animal tests have shown that the drug-loaded cellulose membrane fills the skin in a natural fusion and acts as a natural skin. Therefore, this study laid the foundation for the further development of a broad-spectrum skin-repairing preparation.