脲酶抑制剂的研究综述
A Review of Studies on Urease Inhibitors
DOI: 10.12677/HJMCe.2019.71001, PDF,   
作者: 吴孝婧, 石 蕊, 聂琬纯, 张晓琳, 秦 洁*：山东理工大学，生命科学学院，山东 淄博
关键词: 脲酶；脲酶活性中心；脲酶抑制剂；Urease； Urease Active Center； Urease Inhibitor
摘要: 土壤中的尿素在脲酶的作用下能够被分解为氨气，致使氮利用率降低，人体中的脲酶会引起各种疾病。本文介绍了不同来源的脲酶活性中心的结构及若干抑制剂与活性中心的结合方式，综述了金属离子类、羟肟酸类、磷酰胺类、磷酸盐类、杂环化合物、金属配合物等脲酶抑制剂的研究进展和存在的问题。
Abstract: Urea in soil can be decomposed into ammonia under the action of urease, which reduces the utili-zation rate of nitrogen. Urease in human body causes various diseases. The structure of urease ac-tive centers from different sources and the binding modes of several inhibitors with active centers are introduced. The urease inhibitors of metal ions, hydroxamic acids, phosphoramides, phosphates, heterocyclic compounds and metal complexes are reviewed; the problems and prospect are put forward.
文章引用：吴孝婧, 石蕊, 聂琬纯, 张晓琳, 秦洁. 脲酶抑制剂的研究综述[J]. 药物化学, 2019, 7(1): 1-6. https://doi.org/10.12677/HJMCe.2019.71001

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