吗啡联合普瑞巴林治疗伴焦虑、抑郁状态的癌性神经痛的临床研究

Clinical Study of Morphine Combined with Prednisone in the Treatment of Carcinomatous Neuralgia with Anxiety and Depression

摘要: 目的：研究吗啡联合普瑞巴林治疗伴焦虑、抑郁状态的癌性神经病理性疼痛的疗效。方法：选取我院门诊及住院部癌性神经病理性疼痛伴焦虑、抑郁状态的患者各10例，分为AB两组，A组伴焦虑状态，B组伴抑郁状态。结果：AB两组的患者疼痛均有明显控制，两组焦虑、抑郁状态均有改善，且相关副作用能耐受。结论：吗啡联合普瑞巴林应用于伴有轻、中度焦虑、抑郁状态的中、重度癌性神经病理性疼痛患者是安全有效的。

Abstract: Objective: To study the effect of morphine combined with pregabalin in the treatment of malignant neuropathic pain with anxiety and depression state. Methods: 10 patients with malignant neuropathic pain accompanied by anxiety and depression state were divided into two groups: group A with anxiety state and group B with depression state. Results: Pain in both A B groups was significantly controlled; anxiety and depression state were improved in both groups, and the re-lated side effects were tolerable. Conclusion: Morphine combined with pregabalin is safe and ef-fective in patients with moderate to severe malignant neuropathic pain accompanied by mild to moderate anxiety and depression.