无创双水平正压通气联合枸橼酸咖啡因治疗早产儿频繁呼吸暂停的效果观察

Effect of Noninvasive Bi-Level Positive Pressure Ventilation Combined with Caffeine Citrate on Frequent Apnea in Premature Infants

摘要: 目的：探讨无创双水平正压通气联合枸橼酸咖啡因治疗早产儿频繁呼吸暂停的效果。方法：2015年11月至2017年11月期间，选择94例本院儿科重症监护室收治的早产儿频繁呼吸暂停患儿作为研究资料，随机分组各47例，对照组实施无创双水平正压通气治疗，观察组实施无创双水平正压通气联合枸橼酸咖啡因治疗，观察两组疗效、康复效果及血气指标变化。结果：观察组治疗有效率为93.62%，明显高于对照组76.60%，P < 0.05；观察组康复各指标均显著低于对照组，即康复效果优于对照组，P < 0.05；治疗前两组患儿血气指标比较无明显差异，P > 0.05；治疗后观察组患儿pH值、动脉血氧分压升高，而动脉血二氧化碳分压降低，且变化程度均优于对照组，P < 0.05。结论：选择无创双水平正压通气联合枸橼酸咖啡因治疗早产儿频繁呼吸暂停可有效提高治疗效果，利于进一步改善患儿血气指标，加快康复速度，临床治疗价值较高。

Abstract: Objective: To investigate the effect of non-invasive double-level positive pressure ventilation combined with caffeine citrate in the treatment of frequent apnea in premature infants. Methods: From November 2015 to November 2017, 94 children with frequent apnea in pediatric intensive care unit of our hospital were randomly divided into four groups. The control group was treated with non-invasive double-level positive pressure ventilation. The observation group was treated with noninvasive bi-level positive pressure ventilation combined with caffeine citrate. The curative effect, rehabilitation effect and changes of blood gas index were observed in the two groups. Results: The effective rate of treatment in the observation group was 93.62%, which was significantly higher than that in the control group (76.60%). Each index of rehabilitation in the observation group was significantly shorter than that in the control group (P < 0.05); the rehabilitation effect was better than that in the control group (P < 0.05); there was no significant difference in blood gas index between the two groups before treatment (P > 0.05). The arterial blood partial pressure of carbon dioxide was lower than that of the control group (P < 0.05). Conclusion: The treatment of frequent apnea in premature infants with non-invasive bi-level positive pressure ventilation combined with citrate caffeine can effectively improve the blood gas index and accelerate the recovery rate.