红花注射液眼部电离导入对眼血流动力学的影响研究

Effect of Ionisation of Honghua Injection on Ocular Hemodynamics

摘要: 目的：观察红花注射液电离导入对眼血流动力学的影响研究。方法：本研究共入组31例62眼，均以右眼为实验组，左眼为对照组，实验组予红花注射液10 ml眼部电离导入，对照组予生理盐水10 ml电离导入，通过彩色多普勒超声成像观察红花注射液和生理盐水眼部电离导入前后受试者眼动脉、视网膜中央动脉、睫状动脉血流频谱的变化情况。组间比较采用t检验，治疗前–后比较采用配对t检验。结果：右眼(实验组)红花注射液电离导入前–后均值比较，视网膜中央动脉、睫状动脉、眼动脉收缩期峰值流速、舒张末期流速差异均有统计学意义(P < 0.01)。左眼(对照组)生理盐水电离导入前–后均值比较，睫状动脉、眼动脉各指标前–后差异均无统计学意义(P > 0.05)。电离后两组间仅视网膜中央动脉收缩期峰值流速差异具有统计学意义(P < 0.01)。结论：眼部药物电离导入法能将药物直接透入眼部皮肤或粘膜进入眼内作用于血管。电离导入红花注射液对扩张眼部血管、改善眼部微循环具有重要意义。

Abstract: Objective: To observe the effect of ionization induction of Honghua injection on ocular hemody-namics. Methods: In this study, 31 cases with 62 eyes are grouped. Right eyes are in the experi-mental group, left eye as the control group. The experimental group was given Honghua injection 10 ml eye ionization introduction. The control group was given physiological saline 10 ml ionization introduction. By color Doppler ultrasound imaging, the situation of ophthalmic artery, central retinal artery, spectrum of blood flow in the ciliary artery were observed before and after Honghua injection and physiological saline eye ionization import subjects. T test was used for comparison between groups, and paired t test was used for comparison before and after treatment. Results: The mean values of right eye (experimental group) before and after ionisation of Honghua injection were compared; the differences in the systolic peak velocity and the diastolic end velocity of the central retinal artery, ciliary artery and ophthalmic artery were statistically significant (P < 0.01). Before and after the ionization of normal saline was introduced into the left eye (control group), there was no statistically significant difference between the anterior and posterior indexes of the ciliary artery and ophthalmic artery (P > 0.05). After ionization, only the difference in the systolic peak velocity of the central retinal artery between the two groups was statistically significant (P < 0.01). Conclusions: Iontophoresis can penetrate directly into ocular skin or mucous membrane and act on blood vessels. Ionizing injection of Honghua is of great significance in dilating blood vessels and improving microcirculation around eyes.