用于抗肿瘤药物递送的刺激敏感型聚合物载体的研究进展
Research Progress of Stimuli-Sensitive Polymer Carriers for Anti-Tumor Drug Delivery
DOI: 10.12677/JAPC.2019.84008, PDF,    国家自然科学基金支持
作者: 李景果*：河南省人民医院和郑州大学人民医院，河南 郑州；冯华阳：郑州大学材料科学与工程学院，河南 郑州
关键词: 刺激敏感型聚合物纳米载体；pH敏感；氧化还原敏感；低氧敏感；光敏感；超声波敏感；多重刺激响应；Stimulating Sensitive Polymer Nanocarriers； pH Sensitive； Redox Sensitive； Hypoxic Sensitive； Light Sensitive； Ultrasonic Sensitive； Multiple Stimuli Response
摘要: 刺激敏感型聚合物纳米载体由于在药物递送和药物的智能控释方面具有良好的应用前景，受到了广大研究人员的广泛关注。其种类包括响应内源刺激的pH敏感聚合物载体、氧化还原敏感聚合物载体和低氧敏感聚合物载体，响应外源刺激的光敏感聚合物载体和超声波敏感聚合物载体。本文主要综述不同刺激敏感型聚合物载体和多重刺激响应聚合物载体的研究进展，激励未来的研究人员设计和合成新型刺激响应聚合物载体，以便实现更加高效的药物递送和智能控释的效果。
Abstract: Stimuli-sensitive polymer nanocarriers have attracted much attention from researchers because of their good application prospects in drug delivery and intelligent controlled release of drugs. They consist of pH sensitive polymer carriers, redox sensitive polymer carriers, hypoxic sensitive polymeric carriers, light sensitive polymeric carriers and ultrasonically sensitive polymeric carriers. This article reviews the research progress of different stimuli-sensitive polymer carriers and multiple stimuli-responsive polymer carriers, and encourages future researchers to design and synthesize novel stimuli-responsive polymer carriers for more efficient drug delivery and in-telligent controlled release.
文章引用：李景果, 冯华阳. 用于抗肿瘤药物递送的刺激敏感型聚合物载体的研究进展[J]. 物理化学进展, 2019, 8(4): 65-73. https://doi.org/10.12677/JAPC.2019.84008

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[Google Scholar] [CrossRef] [PubMed]
[77] Alex, M.R.A., Nehate, C., Veeranarayanan, S., et al. (2017) Self Assembled Dual Responsive Micelles Stabilized with Protein for Co-Delivery of Drug and siRNA in Cancer Therapy. Biomaterials, 133, 94-106.
[Google Scholar] [CrossRef] [PubMed]
[78] Teo, J.Y., Chin, W., Ke, X., et al. (2017) pH and Redox Dual-Responsive Biodegradable Polymeric Micelles with High Drug Loading for Effective Anticancer Drug Delivery. Nanomedicine: Nanotechnology, Biology and Medicine, 13, 431-442.
[Google Scholar] [CrossRef] [PubMed]
[79] Zhuang, W., Xu, Y., Li, G., et al. (2018) Redox and pH Dual-Responsive Polymeric Micelles with Aggregation-Induced Emission Feature for Cellular Imaging and Chemotherapy. ACS Applied Materials & Interfaces, 10, 18489-18498.
[Google Scholar] [CrossRef] [PubMed]
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[Google Scholar] [CrossRef] 
[81] Xu, X., Li, L., Zhou, Z., Sun, W. and Huang, Y. (2016) Dual-pH Responsive Micelle Platform for Co-Delivery of Axitinib and Doxorubicin. International Journal of Pharmaceutics, 507, 50-60.
[Google Scholar] [CrossRef] [PubMed]
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[Google Scholar] [CrossRef] 
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[Google Scholar] [CrossRef] [PubMed]
[84] Li, J., Yu, X., Wang, Y., et al. (2014) A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted Sirna Delivery. Advanced Materials, 26, 8217-8224.
[Google Scholar] [CrossRef] [PubMed]