组学与营养学个性化趋势研究进展

Advances of Omics and Personalized Nutrition Trends

摘要: 营养学个性化是快速发展的研究方向，个性化营养对防治慢性病已经变成大众的迫切健康需求。利用组学大数据和整体分析的技术优势，近年来从蛋白组学、营养基因组学、肠道菌宏基因组学和营养代谢组学的诸多研究进展，给个性化营养发展提供了新思路和新手段。分析营养图谱结构可确立精准膳食、依据个体基因数据可选择健康膳食、调整个体饮食习惯及补充肠道菌而改变肠道菌生态以强化营养、对代谢特征物高通量分析而监管个人膳食营养等方面正在指导营养膳食实现个性化，结合网络分析、数据集成、智能整合和交互在线，使得个性化营养从算法和技术上日臻完善，实现个人健康营养快捷指导。营养学个性化需要在临床、行为学、心理学、计算机科学、生物学和营养学多专业全面合作，以提供精准性和系统性指导服务。

Abstract: The research on personalized nutrition is fast-growing. Personalized nutrition is a desired demand for people health to prevent chronic diseases in era. The Omics have the advantages of overall systematic analysis upon big data, from which the recent researches in proteomics, individual nutritional genomics, individual metagenomics on gut microbiome, and nutritional metabolomics were summarized. There after come some new progresses and means for personalized nutrition. Combining aspects such as: the analysis of the nutritional spectrum of nutrition molecular figures to establish suitable diet, tuning selective nutritious diet based on personal genetic data, enhancing the nutrition by changing the intestinal flora after dietary adjustment or supplementation of intestinal bacteria, and regulating individuals diet under high-throughput analysis the metabolic components, personalized nutrition has been come in practical use. Network analysis, omics’ data consolidation, human-machine interaction were either needed for guiding people nutrition personalization conveniently. Moreover, comprehensive integration of clinical, behavioral, psychological, computational, biological and nutritional was perfect for providing accurate, systematic healthy nutrition services to individuals.